PMID- 14617033
OWN - NLM
STAT- MEDLINE
DCOM- 20040722
LR  - 20190827
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 62
IP  - 6
DP  - 2003 Dec
TI  - Single-nucleotide polymorphisms of the interleukin-18 gene promoter region in 
      rheumatoid arthritis patients: protective effect of AA genotype.
PG  - 498-504
AB  - Rheumatoid arthritis (RA) is a chronic arthritic condition that can lead to 
      deformities and disabilities. Although numerous studies reported the association 
      of human leukocyte antigen (HLA)-DRB1*04 and RA, other genes, e.g. cytokines 
      genes, may contribute towards disease susceptibility. Interleukin-18 (IL-18) is a 
      proinflammatory cytokine postulated to play a role in the acute and chronic 
      inflammatory phases of RA. The IL-18 protein expression seems to be regulated by 
      two single-nucleotide polymorphisms (SNPs) located at positions -607 and -137 in 
      the promoter region of the gene. It is postulated that specific alleles may be 
      associated with susceptibility to the development of RA. In the present study, we 
      described the IL-18 gene promoter region genotypes and combined genotypes 
      (-607/-137) in 106 RA patients and 273 unrelated healthy controls to evaluate the 
      contributions of these alleles to RA predisposition in Chinese, Malays, and 
      Indians. The genotyping were performed using sequence-specific polymerase chain 
      reactions. Rheumatoid factors were assayed by enzyme-linked immunosorbent assay. 
      Biodata were obtained through chart review. The controls had significantly higher 
      frequency of AA genotype at position -607 when compared to RA patients. No 
      significant differences were observed in the distribution of either allelic or 
      genotypic frequencies at position -137. There was no association between the 
      genotypes and the presence of rheumatoid factors. This study did not find 
      evidence of a genetic susceptibility factor but demonstrated the novel finding 
      that the AA genotype at position -607 is associated with a protective effect 
      against development of RA in Chinese individuals. This protection may be mediated 
      through inhibition of cyclic (Adenosine 3', 5'-cyclic monophosphate) 
      AMP-responsive element (CRE)-binding protein by the disruption of the CRE 
      consensus sequence.
FAU - Sivalingam, S P
AU  - Sivalingam SP
AD  - Department of Medicine, National University of Singapore, Singapore Department of 
      Physiology, National University of Singapore, Singapore.
FAU - Yoon, K H
AU  - Yoon KH
FAU - Koh, D R
AU  - Koh DR
FAU - Fong, K Y
AU  - Fong KY
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Interleukin-18)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Adult
MH  - Arthritis, Rheumatoid/ethnology/*genetics
MH  - Case-Control Studies
MH  - China/ethnology
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - India/ethnology
MH  - Interleukin-18/*genetics
MH  - Malaysia/ethnology
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Rheumatoid Factor
EDAT- 2003/11/18 05:00
MHDA- 2004/07/23 05:00
CRDT- 2003/11/18 05:00
PHST- 2003/11/18 05:00 [pubmed]
PHST- 2004/07/23 05:00 [medline]
PHST- 2003/11/18 05:00 [entrez]
AID - 137 [pii]
AID - 10.1046/j.1399-0039.2003.00137.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2003 Dec;62(6):498-504. doi: 10.1046/j.1399-0039.2003.00137.x.