PMID- 14621770
OWN - NLM
STAT- MEDLINE
DCOM- 20031223
LR  - 20190917
IS  - 0934-0874 (Print)
IS  - 0934-0874 (Linking)
VI  - 5 Suppl 1
DP  - 1992
TI  - Somatomedin C (IGF I) plasma levels after orthotopic liver transplantation (OLT) 
      in end-stage cirrhotic patients.
PG  - S185-6
AB  - Insulin-like growth factors [IGF I and II or somatomedins (SMS)] are polypeptides 
      chemically and biologically correlated with insulin. The main source of synthetic 
      activity and secretion is the liver, although many other tissues have been 
      demonstrated to synthesize SMS. In the circulation, they are not present in a 
      free form, but are mostly bound to a specific carrier protein independently 
      synthesized in the liver. Hepatic or extrahepatic storage organs have not been 
      demonstrated; the half life of the SMS-binding protein complex is between 3 and 
      4. Synthesis of SMS is regulated by GH, insulin, thyroxine and nutrition (caloric 
      and protein intake, and nitrogen balance). The role of corticosteroids is still a 
      matter of debate: in patients treated with steroids SMS blood levels have been 
      shown to be within normal limits, while biological activity has been demonstrated 
      to be significantly reduced by SMS inhibitors, probably induced by corticosteroid 
      therapy. The biological properties of SMS are related to their structural 
      homology with insulin, and can be summarized as follows: A. Insulin-like activity 
      (glucose oxidation, lipogenesis, glycogen synthesis, inhibition of lipolysis and 
      glycogenolysis); B. Sulphation activity (incorporation of sulphate and leucine 
      into glycosaminglycans of the cartilage); C. Stimulation of fibroblast 
      multiplication; D. Amplification of other hormone activities (GH); E. 
      Complementary anabolic activity with insulin. Low levels of SMS have been 
      demonstrated in hypopituitarism (secondary) or in other diseases independent of 
      GH reduced secretion (primary) such as malnutrition, malabsorption, acute or 
      chronic liver failure and uraemia. Negative nitrogen balance, hypocaloric and/or 
      low protein diets are usually correlated with low levels of SMS. Recently, 
      Schalch et al. reported on the role of orthotopic liver transplantation (OLT) in 
      normalizing SMS blood levels in a group of end-stage liver diseased patients. 
      This preliminary paper deals with changes in IGF-I plasma levels (somatomedin C) 
      in a group of patients affected by end-stage liver cirrhosis before and after 
      OLT.
FAU - Corti, A
AU  - Corti A
AD  - Department of Anaesthesia, Ospedale Niguarda Ca'Granda, Milano, Italy.
FAU - De Gasperi, A
AU  - De Gasperi A
FAU - Oppizzi, G
AU  - Oppizzi G
FAU - Pannacciulli, E
AU  - Pannacciulli E
FAU - Cristalli, A
AU  - Cristalli A
FAU - Fantini, G
AU  - Fantini G
FAU - Mazza, E
AU  - Mazza E
FAU - Prosperi, M
AU  - Prosperi M
FAU - Rocchini, A
AU  - Rocchini A
FAU - Sabbadini, D
AU  - Sabbadini D
FAU - Savi, C
AU  - Savi C
FAU - Scaiola, A
AU  - Scaiola A
FAU - Vai, S
AU  - Vai S
FAU - Romani, F
AU  - Romani F
FAU - DeCarlis, L
AU  - DeCarlis L
FAU - Rondinara, G F
AU  - Rondinara GF
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
RN  - 0 (Immunosuppressive Agents)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
SB  - IM
MH  - Bile/metabolism
MH  - Female
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Insulin-Like Growth Factor II/*metabolism
MH  - Liver Cirrhosis/blood/classification/pathology/*surgery
MH  - Liver Transplantation/*physiology
MH  - Male
MH  - Necrosis
EDAT- 1992/01/01 00:00
MHDA- 2003/12/24 05:00
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 2003/12/24 05:00 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1007/978-3-642-77423-2_57 [doi]
PST - ppublish
SO  - Transpl Int. 1992;5 Suppl 1:S185-6. doi: 10.1007/978-3-642-77423-2_57.