PMID- 14622146
OWN - NLM
STAT- MEDLINE
DCOM- 20040116
LR  - 20220310
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 18
IP  - 9
DP  - 2003 Nov
TI  - Effect of NT-4 and BDNF delivery to damaged sciatic nerves on phenotypic recovery 
      of fast and slow muscles fibres.
PG  - 2460-6
AB  - We investigated whether neurotrophin-4 (NT-4) and brain-derived neurotrophic 
      factor (BDNF) affected the reinnervation of slow and fast motor units. 
      Neurotrophin-impregnated or plain fibronectin (FN) conduits were inserted into a 
      sciatic nerve gap. Fast extensor digitorum longus (EDL) and slow soleus muscles 
      were collected 4 months postsurgery. Muscles were weighed and fibre type 
      proportion and mean fibre diameters were derived from muscle cross-sections. All 
      fibre types in muscles from FN animals were severely atrophied and this 
      correlated well with type 1 fibre loss and atrophy in soleus and type 2b loss and 
      atrophy in EDL. Treatment with NT-4 reversed soleus but not EDL mass loss above 
      the FN group by significantly restoring type 1 muscle fibre proportion and 
      diameters towards those of normal unoperated animals. BDNF did not increase 
      muscle mass but did have minor effects on fibre type and diameter. Thus, NT-4 
      significantly improved slow motor unit recovery, and provides a basis for 
      therapies intended to aid the functional recovery of muscles after denervating 
      injury.
FAU - Simon, Magda
AU  - Simon M
AD  - Blond McIndoe Centre, Royal Free and University College Medical School, London, 
      UK.
FAU - Porter, Rebecca
AU  - Porter R
FAU - Brown, Robert
AU  - Brown R
FAU - Coulton, Gary R
AU  - Coulton GR
FAU - Terenghi, Giorgio
AU  - Terenghi G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/administration & dosage/*metabolism
MH  - Male
MH  - Muscle Fibers, Fast-Twitch/*drug effects/metabolism
MH  - Muscle Fibers, Slow-Twitch/*drug effects/metabolism
MH  - Muscle, Skeletal/*drug effects/*innervation/metabolism
MH  - Nerve Growth Factors/administration & dosage/*metabolism
MH  - Nerve Regeneration
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Sciatic Nerve/*drug effects/metabolism
EDAT- 2003/11/19 05:00
MHDA- 2004/01/17 05:00
CRDT- 2003/11/19 05:00
PHST- 2003/11/19 05:00 [pubmed]
PHST- 2004/01/17 05:00 [medline]
PHST- 2003/11/19 05:00 [entrez]
AID - 2978 [pii]
AID - 10.1046/j.1460-9568.2003.02978.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2003 Nov;18(9):2460-6. doi: 10.1046/j.1460-9568.2003.02978.x.