PMID- 14623369
OWN - NLM
STAT- MEDLINE
DCOM- 20040406
LR  - 20190917
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 65
IP  - 1
DP  - 2003 Dec 1
TI  - The C270T polymorphism of the brain-derived neurotrophic factor gene is 
      associated with schizophrenia.
PG  - 15-8
AB  - We investigated a novel polymorphism of single nucleotide substitution (C270T) of 
      the brain-derived neurotrophic factor (BDNF) gene in schizophrenia patients 
      (n=101) and in controls (n=68). The frequency of the C/T genotype and the T 
      allele were significantly higher in the schizophrenia patients (25.7% and 13.9%, 
      respectively) compared with the controls (5.9% and 2.9%). There were no 
      significant differences in Positive and Negative Symptom Scale (PANSS) items and 
      Global Assessment of Functioning (GAF) scores between the patients with C/C and 
      C/T genotypes. Further studies are warranted to elucidate the significance of 
      this finding in the pathophysiology of schizophrenia.
FAU - Szekeres, Gyorgy
AU  - Szekeres G
AD  - Department of Psychiatry, University of Szeged, Semmelweis u. 6., H-6725, Szeged, 
      Hungary.
FAU - Juhasz, Anna
AU  - Juhasz A
FAU - Rimanoczy, Agnes
AU  - Rimanoczy A
FAU - Keri, Szabolcs
AU  - Keri S
FAU - Janka, Zoltan
AU  - Janka Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/diagnosis/*genetics
MH  - *Schizophrenic Psychology
EDAT- 2003/11/19 05:00
MHDA- 2004/04/07 05:00
CRDT- 2003/11/19 05:00
PHST- 2003/11/19 05:00 [pubmed]
PHST- 2004/04/07 05:00 [medline]
PHST- 2003/11/19 05:00 [entrez]
AID - S0920996402005054 [pii]
AID - 10.1016/s0920-9964(02)00505-4 [doi]
PST - ppublish
SO  - Schizophr Res. 2003 Dec 1;65(1):15-8. doi: 10.1016/s0920-9964(02)00505-4.