PMID- 14624401
OWN - NLM
STAT- MEDLINE
DCOM- 20031212
LR  - 20190725
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 52
IP  - 11
DP  - 2003 Nov
TI  - Differential effects of high-fat and high-carbohydrate isoenergetic meals on 
      cardiac autonomic nervous system activity in lean and obese women.
PG  - 1426-32
AB  - Food ingestion can influence autonomic nervous system activity. This study 
      compares the effects of 2 different isoenergetic meals on sympathetic nervous 
      system (SNS) activity, assessed by heart rate variability (HRV) and plasma 
      norepinephrine (NE) levels, in lean and obese women. Fifteen lean and 15 obese 
      healthy women were examined on 2 occasions: after a carbohydrate (CHO)-rich and 
      after a fat-rich test meal. Measurements of blood pressure, heart rate, resting 
      energy expenditure, plasma glucose, lipids, insulin, leptin, and NE, as well as 
      spectral analysis of the HRV, were performed at baseline and every 1 hour for 3 
      hours after meals. At baseline, obese women had higher SNS activity than lean 
      controls (higher values of low-to-high frequency ratio [LF/HF], 1.52 +/- 0.31 v 
      0.78 +/- 0.13, P=.04; and plasma NE levels, 405.6 +/- 197.9 v 240.5 +/- 95.8 
      pg/mL, P<.0001). After the CHO-rich meal a greater increase in LF/HF and in 
      plasma NE levels was observed in lean, compared to obese women (1.21 +/- 0.6 v 
      0.32 +/- 0.06, P=.04; and 102.9 +/- 35.4 v 38.7 +/- 12.3 pg/mL, P=.01, 
      respectively), while no differences were observed after the fat-rich meal. 
      Meal-induced thermogenesis was higher after the CHO-rich as compared to the 
      fat-rich meal and was comparable between lean and obese women. Changes in HRV 
      were not associated with the thermogenic response to the test meals. In 
      conclusion, consumption of a CHO-rich meal causes greater cardiac SNS activation 
      in lean than in obese women, while fat ingestion does not result in any 
      appreciable change in either group. SNS activation does not appear to influence 
      the thermic effect of the food in either lean or obese women.
FAU - Tentolouris, N
AU  - Tentolouris N
AD  - First Department of Propaedeutic Medicine, Athens University Medical School, 
      Laiko Hospital, Athens, Greece.
FAU - Tsigos, C
AU  - Tsigos C
FAU - Perea, D
AU  - Perea D
FAU - Koukou, E
AU  - Koukou E
FAU - Kyriaki, D
AU  - Kyriaki D
FAU - Kitsou, E
AU  - Kitsou E
FAU - Daskas, S
AU  - Daskas S
FAU - Daifotis, Z
AU  - Daifotis Z
FAU - Makrilakis, K
AU  - Makrilakis K
FAU - Raptis, S A
AU  - Raptis SA
FAU - Katsilambros, N
AU  - Katsilambros N
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adult
MH  - Area Under Curve
MH  - Autonomic Nervous System/drug effects/*physiology
MH  - Blood Pressure/drug effects/physiology
MH  - Body Temperature Regulation/drug effects
MH  - Cholesterol/blood
MH  - Cross-Over Studies
MH  - Dietary Carbohydrates/*pharmacology
MH  - Dietary Fats/*pharmacology
MH  - Energy Metabolism/drug effects
MH  - Female
MH  - Heart/drug effects/*physiology
MH  - Heart Rate/drug effects/physiology
MH  - Humans
MH  - Insulin/blood
MH  - Leptin/blood
MH  - Middle Aged
MH  - Norepinephrine/blood
MH  - Obesity/*physiopathology
MH  - Postprandial Period/physiology
MH  - Pulmonary Gas Exchange/physiology
EDAT- 2003/11/19 05:00
MHDA- 2003/12/13 05:00
CRDT- 2003/11/19 05:00
PHST- 2003/11/19 05:00 [pubmed]
PHST- 2003/12/13 05:00 [medline]
PHST- 2003/11/19 05:00 [entrez]
AID - S0026049503003226 [pii]
AID - 10.1016/s0026-0495(03)00322-6 [doi]
PST - ppublish
SO  - Metabolism. 2003 Nov;52(11):1426-32. doi: 10.1016/s0026-0495(03)00322-6.