PMID- 14625444
OWN - NLM
STAT- MEDLINE
DCOM- 20040525
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 14
IP  - 17
DP  - 2003 Dec 2
TI  - Differential influence of BDNF and NT3 on the expression of calcium binding 
      proteins and neuropeptide Y in vivo.
PG  - 2183-7
AB  - Neurotrophins enhance and maintain some neuronal phenotypes and suppress others 
      by influencing the expression of neuropeptides and calcium binding proteins, 
      thereby affecting many different physiological functions of the brain. 
      Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) show different 
      effects on neuronal phenotypes despite largely overlapping expression of their 
      respective receptors, TrkB and TrkC. Using BDNF null mutant (BDNF-/-) mice and 
      mice where the protein coding DNA sequence of BDNF has been replaced by NT3 
      (BDNFNT3/NT3 mice), we have analysed the roles of BDNF and NT3 in controlling 
      neuropeptide and calcium binding protein expression in the brain. Our results 
      show that NT3 expressed emporally and spatially in the place of BDNF is 
      sufficient in some neuronal populations to compensate for the loss of BDNF.
FAU - Agerman, Karin
AU  - Agerman K
AD  - Unit of Molecular Neurobiology, MBB Department of Physiology and Pharmacology, 
      Karolinska Institutet, 171 77 Stockholm, Sweden.
FAU - Ernfors, Patrik
AU  - Ernfors P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Neurotrophin 3)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/deficiency/genetics/*physiology
MH  - Calcium-Binding Proteins/*biosynthesis/genetics
MH  - Gene Expression Regulation/physiology
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Neuropeptide Y/*biosynthesis/genetics
MH  - Neurotrophin 3/biosynthesis/genetics/*physiology
EDAT- 2003/11/20 05:00
MHDA- 2004/05/27 05:00
CRDT- 2003/11/20 05:00
PHST- 2003/11/20 05:00 [pubmed]
PHST- 2004/05/27 05:00 [medline]
PHST- 2003/11/20 05:00 [entrez]
AID - 10.1097/00001756-200312020-00010 [doi]
PST - ppublish
SO  - Neuroreport. 2003 Dec 2;14(17):2183-7. doi: 10.1097/00001756-200312020-00010.