PMID- 14626631
OWN - NLM
STAT- MEDLINE
DCOM- 20031202
LR  - 20081121
IS  - 0300-9742 (Print)
IS  - 0300-9742 (Linking)
VI  - 32
IP  - 4
DP  - 2003
TI  - Functional polymorphisms in matrix metalloproteinase-1 and monocyte 
      chemoattractant protein-1 and rheumatoid arthritis.
PG  - 235-9
AB  - The aim of this study is to investigate whether the functional polymorphisms in 
      the promoter of matrix metalloproteinase-1 (MMP-1) and in the regulatory region 
      of the monocyte chemoattractant protein-1 (MCP-1) gene are associated with 
      susceptibility to rheumatoid arthritis (RA) and its clinical features. The MMP-1 
      1G/2G polymorphism and the MCP-1 promoter A/G polymorphism were determined by 
      polymerase chain reaction-restriction fragment length polymorphism in 117 RA 
      patients and 97 healthy controls. The genotype distribution of the MMP-1 promoter 
      did not differ between RA patients and control subjects. However, in the 2G/2G 
      genotype, ESR and Plat were higher than the 1G/1G genotype. The genotype 
      distribution of the MCP-1 promoter did not differ between the RA and control 
      groups. Clinically there was no significant difference among RA patients 
      according to the MCP-1 promoter genotypes. Our data show that the functional 
      promoter polymorphism in the MMP-1 promoter may not play an important role in the 
      susceptibility of RA, but the polymorphism may be related to clinical phenotypes.
FAU - Lee, Y H
AU  - Lee YH
AD  - Division of Rheumatology, Department of Internal Medicine, College of Medicine, 
      Korea University, Seoul, Korea.
FAU - Kim, H J
AU  - Kim HJ
FAU - Rho, Y H
AU  - Rho YH
FAU - Choi, S J
AU  - Choi SJ
FAU - Ji, J D
AU  - Ji JD
FAU - Song, G G
AU  - Song GG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Rheumatol
JT  - Scandinavian journal of rheumatology
JID - 0321213
RN  - 0 (Chemokine CCL2)
RN  - 0 (DNA Primers)
RN  - 9007-49-2 (DNA)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arthritis, Rheumatoid/*genetics/physiopathology
MH  - Chemokine CCL2/*genetics
MH  - DNA/analysis
MH  - DNA Primers/chemistry
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 1/*genetics
MH  - Middle Aged
MH  - Point Mutation
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Restriction Fragment Length
MH  - *Promoter Regions, Genetic
EDAT- 2003/11/25 05:00
MHDA- 2003/12/03 05:00
CRDT- 2003/11/25 05:00
PHST- 2003/11/25 05:00 [pubmed]
PHST- 2003/12/03 05:00 [medline]
PHST- 2003/11/25 05:00 [entrez]
PST - ppublish
SO  - Scand J Rheumatol. 2003;32(4):235-9.