PMID- 14628447
OWN - NLM
STAT- MEDLINE
DCOM- 20040520
LR  - 20131121
IS  - 0513-4870 (Print)
IS  - 0513-4870 (Linking)
VI  - 38
IP  - 8
DP  - 2003 Aug
TI  - [Inhibition of MCP-1 mRNA expression by propylene glycol mannate sulfate in 
      hyperlipidemic rat aorta].
PG  - 582-5
AB  - AIM: To study the effects of prophylene glycol mannate sulfate (PGMS) on monocyte 
      chemoattractant protein-1 (MCP-1) mRNA expression in hyperlipidemic rat aorta and 
      to clarify the molecular mechanism of PGMS for the prevention of atherosclerosis. 
      METHODS: PGMS (37.8 and 75.6 mg.kg-1.d-1, ig) or PGMS (37.8 and 75.6 mg.kg-1.d-1, 
      ig) combined with diethyldithiocarbamate (DDC, an inhibitor of SOD, 200 mg.kg-1 
      every three days, i.p.) were given to hyperlipidemic rats for three weeks. The 
      MDA content and SOD activity were determined after 12 h of starvation, and MCP-1 
      mRNA expression in aorta was detected by reverse transcription-polymerase chain 
      reaction (RT-PCR). RESULTS: There was significant decrease (29.46% or 58.40)% of 
      MCP-1 mRNA expression in aortic after the therapy. The SOD activity increased 
      markedly and the MDA content decreased at the same time. After treatment with 
      DDC, the SOD activity was inhibited and the MDA content increased, but with no 
      significant effect on MCP-1 mRNA expression. CONCLUSION: PGMS inhibited MCP-1 
      mRNA expression with no relation to its effect on decreasing MDA content.
FAU - Gao, Yan
AU  - Gao Y
AD  - Institute of Marine Drugs and Foods, Ocean University of China, Qingdao 266003, 
      China.
FAU - Yu, Wen-gong
AU  - Yu WG
FAU - Han, Feng
AU  - Han F
FAU - Lu, Xin-zhi
AU  - Lu XZ
FAU - Gong, Qian-hong
AU  - Gong QH
FAU - Guan, Hua-shi
AU  - Guan HS
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Yao Xue Xue Bao
JT  - Yao xue xue bao = Acta pharmaceutica Sinica
JID - 21710340R
RN  - 0 (Chemokine CCL2)
RN  - 0 (Hypolipidemic Agents)
RN  - 0 (Propylene Glycols)
RN  - 0 (RNA, Messenger)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Aorta, Thoracic/*drug effects/metabolism
MH  - Chemokine CCL2/*biosynthesis/genetics
MH  - Gene Expression/*drug effects
MH  - Hyperlipidemias/blood/pathology
MH  - Hypolipidemic Agents/*pharmacology
MH  - Male
MH  - Malondialdehyde/blood/metabolism
MH  - Propylene Glycols/*pharmacology
MH  - RNA, Messenger/biosynthesis/drug effects
MH  - Random Allocation
MH  - Rats
MH  - Rats, Wistar
MH  - Superoxide Dismutase/blood/metabolism
EDAT- 2003/11/25 05:00
MHDA- 2004/05/21 05:00
CRDT- 2003/11/25 05:00
PHST- 2003/11/25 05:00 [pubmed]
PHST- 2004/05/21 05:00 [medline]
PHST- 2003/11/25 05:00 [entrez]
PST - ppublish
SO  - Yao Xue Xue Bao. 2003 Aug;38(8):582-5.