PMID- 14629094
OWN - NLM
STAT- MEDLINE
DCOM- 20040112
LR  - 20041117
IS  - 1476-7058 (Print)
IS  - 1476-4954 (Linking)
VI  - 14
IP  - 2
DP  - 2003 Aug
TI  - Biological implications of bi-directional fetomaternal cell traffic: a summary of 
      a National Institute of Child Health and Human Development-sponsored conference.
PG  - 123-9
AB  - OBJECTIVE: The National Institute of Child Health and Human Development (NICHD) 
      held a workshop on 27-28 July 2000 to bring together investigators working in the 
      field of fetomaternal cellular and nucleic acid trafficking with the hope that 
      this would stimulate further research into the biological implications of such 
      phenomena. METHODS: Invited speakers from all over the world presented their 
      latest (unpublished) data. The conference proceedings were delayed until the 
      present time to allow independent publication of the primary data. RESULTS AND 
      CONCLUSIONS: Bi-directional fetomaternal trafficking of cells and nucleic acids 
      during pregnancy is now well established, through the use of molecular techniques 
      including conventional and real-time polymerase chain reaction, as well as 
      fluorescence in situ hybridization. In addition, human leukocyte antigen (HLA) is 
      deposited in the skin of pregnant women. Fetomaternal trafficking is increased in 
      some complications of pregnancy, such as pre-eclampsia, polyhydramnios, 
      polymorphic eruption of pregnancy, preterm labor and specific fetal chromosome 
      aneuploidies. Maternal cells and nucleic acids have been documented in umbilical 
      cord blood and in autopsy tissue of non-transfused neonates. Fetal cells persist 
      postpartum and may be associated with the development of disorders such as 
      scleroderma, lichen planus, lupus and thyroid disease. The extent of fetomaternal 
      trafficking may be affected by three generational HLA relationships. Thus, the 
      consequences of pregnancy extend beyond gestation.
FAU - Bianchi, D W
AU  - Bianchi DW
AD  - Division of Genetics, Tufts-New England Medical Center, Boston, Massachusetts 
      02111, USA.
FAU - Romero, R
AU  - Romero R
LA  - eng
PT  - Consensus Development Conference
PT  - Consensus Development Conference, NIH
PT  - Journal Article
PT  - Review
PL  - England
TA  - J Matern Fetal Neonatal Med
JT  - The journal of maternal-fetal & neonatal medicine : the official journal of the 
      European Association of Perinatal Medicine, the Federation of Asia and Oceania 
      Perinatal Societies, the International Society of Perinatal Obstetricians
JID - 101136916
SB  - IM
MH  - Female
MH  - Fetal Blood/*cytology
MH  - Humans
MH  - *Maternal-Fetal Exchange
MH  - Pregnancy/*blood
RF  - 35
EDAT- 2003/11/25 05:00
MHDA- 2004/01/13 05:00
CRDT- 2003/11/25 05:00
PHST- 2003/11/25 05:00 [pubmed]
PHST- 2004/01/13 05:00 [medline]
PHST- 2003/11/25 05:00 [entrez]
AID - 10.1080/jmf.14.2.123.129 [doi]
PST - ppublish
SO  - J Matern Fetal Neonatal Med. 2003 Aug;14(2):123-9. doi: 10.1080/jmf.14.2.123.129.