PMID- 14629723
OWN - NLM
STAT- MEDLINE
DCOM- 20040701
LR  - 20191026
IS  - 0893-5785 (Print)
IS  - 0893-5785 (Linking)
VI  - 16
IP  - 6
DP  - 2003 Dec
TI  - The Bh (black at hatch) gene that causes abnormal feather pigmentation maps to 
      chromosome 1 of the Japanese quail.
PG  - 656-61
AB  - Japanese quail embryos normally have longitudinal black and brown stripes formed 
      by colored feather buds on their back whereas an autosomal dominant mutation, 
      black at hatch (Bh), disrupts this pigmentation pattern by causing overall black 
      and brown coating in heterozygotes and homozygotes, respectively. These 
      phenotypes of the Bh mutant embryos suggest that the Bh locus plays an important 
      role in the pigment pattern formation of plumage, but its genetic origin, 
      including cloning of the responsible gene, has been insufficiently studied. In 
      this study, we adapted genetically directed representational difference analysis 
      with elimination of excessive clones (GDRDA-WEEC) to Bh quails and isolated two 
      genetic markers linked to the Bh locus as DNA fragments. Cytogenetic study by 
      fluorescence in situ hybridization (FISH) of the DNA fragments used as probes 
      demonstrated that the marker loci were located in the same region on the long arm 
      of chromosome 1. Close genetic linkage between the Bh and the marker loci, and 
      the chromosomal location of the latter suggested that the Bh locus is located on 
      the long-arm of chromosome 1 of the Japanese quail.
FAU - Niwa, Tohru
AU  - Niwa T
AD  - Department of Biology, Faculty of Science, Shizuoka University, 836 Oya, Shizuoka 
      422-8529, Japan.
FAU - Shibusawa, Mami
AU  - Shibusawa M
FAU - Matsuda, Yoichi
AU  - Matsuda Y
FAU - Terashima, Akira
AU  - Terashima A
FAU - Nakamura, Akira
AU  - Nakamura A
FAU - Shiojiri, Nobuyoshi
AU  - Shiojiri N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Pigment Cell Res
JT  - Pigment cell research
JID - 8800247
SB  - IM
MH  - Animals
MH  - Chromosome Mapping
MH  - Coturnix/embryology/*genetics/metabolism
MH  - Embryo, Nonmammalian/metabolism
MH  - Feathers/*embryology/metabolism
MH  - Gene Expression Regulation, Developmental/genetics
MH  - Heterozygote
MH  - Homozygote
MH  - In Situ Hybridization, Fluorescence
MH  - *Mutation
MH  - Pigmentation/*genetics/physiology
MH  - Polymorphism, Restriction Fragment Length
EDAT- 2003/11/25 05:00
MHDA- 2004/07/02 05:00
CRDT- 2003/11/25 05:00
PHST- 2003/11/25 05:00 [pubmed]
PHST- 2004/07/02 05:00 [medline]
PHST- 2003/11/25 05:00 [entrez]
AID - 096 [pii]
AID - 10.1046/j.1600-0749.2003.00096.x [doi]
PST - ppublish
SO  - Pigment Cell Res. 2003 Dec;16(6):656-61. doi: 10.1046/j.1600-0749.2003.00096.x.