PMID- 14630994
OWN - NLM
STAT- MEDLINE
DCOM- 20040903
LR  - 20061115
IS  - 0031-3998 (Print)
IS  - 0031-3998 (Linking)
VI  - 55
IP  - 2
DP  - 2004 Feb
TI  - Helper T-lymphocyte-related chemokines in healthy newborns.
PG  - 334-8
AB  - Atopic disease is characterized by an imbalance in cytokines secreted from Th1 
      and Th2 lymphocytes. The association between atopy and serum levels of 
      atopy-related chemokines in umbilical cord blood (UCB) has not been evaluated. 
      This study formulates the reference ranges of thymus and activation-regulated 
      chemokine (TARC), macrophage-derived chemokine (MDC), eotaxin (EOX), monocyte 
      chemotactic protein 1 (MCP-1), and interferon-gamma-inducible protein 10 (IP-10) 
      in UCB of term neonates and investigates the relation between these chemokines 
      and the development of atopy during infancy. The concentrations of total IgE and 
      chemokines in UCB serum were measured by microparticle immunoassay and sandwich 
      enzyme immunoassay, respectively. A total of 124 singleton healthy newborns were 
      investigated. Fifty-three (43%) infants had family history of allergic diseases, 
      and 26 (21%) had increased serum total IgE concentrations. The median 
      (interquartile range) serum TARC, MDC, EOX, MCP-1, and IP-10 concentrations, in 
      pg/mL, were 425 (300-639), 786 (561-1050), 36 (28-45), 156 (116-205), and 38 
      (29-49), respectively. Multiparity was associated with increased serum MDC (p = 
      0.017). Serum chemokine concentrations were not associated with total IgE levels 
      or family history of allergies. The median (interquartile range) serum MDC 
      concentrations in newborns who developed wheezing during infancy and those 
      without wheezing were 1259 pg/mL (945-1523) and 782 pg/mL (551-992), respectively 
      (p = 0.010). This study provides reference ranges of Th-specific chemokines in 
      UCB serum of singleton term neonates. Increased serum MDC concentrations at birth 
      are associated with the occurrence of wheezing during infancy.
FAU - Leung, Ting-Fan
AU  - Leung TF
AD  - Department of Pediatrics, The Chinese University of Hong kong, Prince of Wales 
      Hospital, 6/F, Clinical Sciences Building, Shatin, Hong Kong. 
      leung2142@cuhk.edu.hk
FAU - Ng, Pak-Cheung
AU  - Ng PC
FAU - Tam, Wing-Hung
AU  - Tam WH
FAU - Li, Chung-Yi
AU  - Li CY
FAU - Wong, Eric
AU  - Wong E
FAU - Ma, Terence P Y
AU  - Ma TP
FAU - Lam, Christopher W K
AU  - Lam CW
FAU - Fok, Tai-Fai
AU  - Fok TF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20031119
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Chemokines)
RN  - 0 (Immunoglobulin A)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Chemokines/*blood
MH  - Female
MH  - Fetal Blood/immunology
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypersensitivity/*immunology/*metabolism
MH  - Immunoglobulin A/blood
MH  - Immunoglobulin E/blood
MH  - Infant, Newborn
MH  - Male
MH  - Respiratory Sounds/immunology
MH  - Th1 Cells/*metabolism
MH  - Th2 Cells/*metabolism
EDAT- 2003/11/25 05:00
MHDA- 2004/09/04 05:00
CRDT- 2003/11/25 05:00
PHST- 2003/11/25 05:00 [pubmed]
PHST- 2004/09/04 05:00 [medline]
PHST- 2003/11/25 05:00 [entrez]
AID - 01.PDR.0000102456.03407.84 [pii]
AID - 10.1203/01.PDR.0000102456.03407.84 [doi]
PST - ppublish
SO  - Pediatr Res. 2004 Feb;55(2):334-8. doi: 10.1203/01.PDR.0000102456.03407.84. Epub 
      2003 Nov 19.