PMID- 14631747
OWN - NLM
STAT- MEDLINE
DCOM- 20040210
LR  - 20180222
IS  - 0029-0831 (Print)
IS  - 0029-0831 (Linking)
VI  - 35
IP  - 6
DP  - 2003 Nov
TI  - [A six year-old case of narcolepsy].
PG  - 505-10
AB  - We report here a 6-year-old boy with narcolepsy. The diagnostic criteria were met 
      by the clinical symptoms including excessive daytime sleepiness and cataplexy, 
      and by the results of overnight polysomnography (PSG), multiple sleep latency 
      test (MSLT), and human leukocyte antigen (HLA). PSG showed increased ratio of 
      sleep stages 1 and 2 due to frequent awakening. All the five test session of MSLT 
      showed a sleep onset REM period. HLA typing was positive for DRB1* 1501 and DQB1* 
      0602. Though the present case had very early onset, all the clinical symptoms and 
      results of sleep studies met the criteria of narcolepsy. The CSF orexin level was 
      far below the lower limit of the control values. It is very useful to measure CSF 
      orexin for the diagnosis of early onset narcolepsy.
FAU - Fujii, Yukiharu
AU  - Fujii Y
AD  - Department of Pediatric Neurology, National Center Hospital for Mental, Nervous 
      and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, 
      Tokyo.
FAU - Fukumizu, Michio
AU  - Fukumizu M
FAU - Sugai, Kenji
AU  - Sugai K
FAU - Kanbayashi, Takashi
AU  - Kanbayashi T
FAU - Oyama, Kazushige
AU  - Oyama K
FAU - Kamei, Atushi
AU  - Kamei A
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - No To Hattatsu
JT  - No to hattatsu = Brain and development
JID - 0215224
RN  - 0 (Biomarkers)
RN  - 0 (Carrier Proteins)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Orexins)
SB  - IM
MH  - Biomarkers/analysis
MH  - Carrier Proteins/cerebrospinal fluid
MH  - Child
MH  - Diagnosis, Differential
MH  - HLA-DQ Antigens/analysis
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/analysis
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - *Intracellular Signaling Peptides and Proteins
MH  - Male
MH  - *Membrane Glycoproteins
MH  - Narcolepsy/*diagnosis
MH  - Neuropeptides/cerebrospinal fluid
MH  - Orexins
MH  - Polysomnography
MH  - Sleep, REM
EDAT- 2003/11/25 05:00
MHDA- 2004/02/11 05:00
CRDT- 2003/11/25 05:00
PHST- 2003/11/25 05:00 [pubmed]
PHST- 2004/02/11 05:00 [medline]
PHST- 2003/11/25 05:00 [entrez]
PST - ppublish
SO  - No To Hattatsu. 2003 Nov;35(6):505-10.