PMID- 14632728
OWN - NLM
STAT- MEDLINE
DCOM- 20040720
LR  - 20191108
IS  - 0956-5507 (Print)
IS  - 0956-5507 (Linking)
VI  - 14
IP  - 6
DP  - 2003 Dec
TI  - TOP2A and HER-2 gene amplification in fine needle aspirates from breast 
      carcinomas.
PG  - 314-9
AB  - The TOP2A gene is located on chromosome 17 close to the HER-2 gene. It encodes an 
      enzyme involved in the regulation of cell proliferation. Using fluorescence in 
      situ hybridization (FISH), we have examined fine needle aspiration smears from 42 
      cases of breast carcinoma with probes for TOP2A, HER-2 and chromosome 17. We 
      found that amplification of TOP2A is a frequent finding in breast cancer and is 
      often but not exclusively accompanied by HER-2 gene amplification. It is 
      associated with high histological grade and oestrogen receptor (ER) negativity. 
      TOP2A deletions may also be associated with high histological grade and loss of 
      ER. TOP2A amplification in the absence of HER-2 amplification may be associated 
      with lower histological grade and ER positivity. Testing for TOP2A aberrations 
      may be useful in the search for individually tailored treatment regimes for 
      breast cancer.
FAU - Bofin, A M
AU  - Bofin AM
AD  - Department of Laboratory Medicine, Children's and Women's Health, Norwegian 
      University of Science and Technology, Trondheim, Norway. 
      anna.bofin@medisin.ntnu.no
FAU - Ytterhus, B
AU  - Ytterhus B
FAU - Hagmar, B M
AU  - Hagmar BM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cytopathology
JT  - Cytopathology : official journal of the British Society for Clinical Cytology
JID - 9010345
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Poly-ADP-Ribose Binding Proteins)
RN  - EC 5.99.1.3 (DNA Topoisomerases, Type II)
RN  - EC 5.99.1.3 (TOP2A protein, human)
SB  - IM
CIN - Cytopathology. 2003 Dec;14(6):309-13. PMID: 14632727
MH  - Antigens, Neoplasm/*genetics
MH  - *Biopsy, Fine-Needle
MH  - Breast Neoplasms/enzymology/*genetics/pathology
MH  - Carcinoma/enzymology/*genetics/pathology
MH  - DNA Topoisomerases, Type II/*genetics
MH  - DNA-Binding Proteins
MH  - Female
MH  - *Gene Amplification
MH  - Genes, erbB-2/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Poly-ADP-Ribose Binding Proteins
EDAT- 2003/11/25 05:00
MHDA- 2004/07/21 05:00
CRDT- 2003/11/25 05:00
PHST- 2003/11/25 05:00 [pubmed]
PHST- 2004/07/21 05:00 [medline]
PHST- 2003/11/25 05:00 [entrez]
AID - 088 [pii]
AID - 10.1046/j.0956-5507.2003.00088.x [doi]
PST - ppublish
SO  - Cytopathology. 2003 Dec;14(6):314-9. doi: 10.1046/j.0956-5507.2003.00088.x.