PMID- 1463606
OWN - NLM
STAT- MEDLINE
DCOM- 19930121
LR  - 20190819
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 9
IP  - 6
DP  - 1992 Dec
TI  - Changes in neurotrophin responsiveness during the development of cerebellar 
      granule neurons.
PG  - 1041-52
AB  - Neurotrophins and their receptors are widespread in the developing and mature 
      CNS. Identifying the differentiation state of neurotrophin-responsive cells 
      provides a basis for understanding the developmental functions of these factors. 
      Studies using dissociated and organotypic cultures of rat cerebellum demonstrated 
      that the neurotrophins brain-derived neurotrophic factor (BDNF) and 
      neurotrophin-3 (NT-3) affect developing granule cells at distinct stages in 
      differentiation. While early granule neurons in the external germinal layer 
      responded to BDNF, more mature granule cells responded to NT-3. BDNF, but not 
      NT-3, enhanced survival of granule cells in cultures of embryonic cerebella. 
      Thus, BDNF and NT-3 have distinct sequential functions that are likely to be 
      critical in the development of the cerebellum. BDNF may promote the initial 
      commitment, while NT-3 may direct the subsequent maturation of granule cells.
FAU - Segal, R A
AU  - Segal RA
AD  - Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
FAU - Takahashi, H
AU  - Takahashi H
FAU - McKay, R D
AU  - McKay RD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (RNA, Messenger)
RN  - VC2W18DGKR (Thymidine)
SB  - IM
GS  - c-fos
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor
MH  - Cell Differentiation/drug effects
MH  - Cells, Cultured
MH  - Cerebellum/cytology/*physiology
MH  - Fetus
MH  - Gene Expression/drug effects
MH  - Genes, fos/*drug effects
MH  - Nerve Growth Factors/*pharmacology
MH  - Nerve Tissue Proteins/*pharmacology
MH  - Neurons/cytology/drug effects/*physiology
MH  - Neurotrophin 3
MH  - Organ Culture Techniques
MH  - Proto-Oncogene Proteins c-fos/analysis/biosynthesis
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Thymidine/metabolism
EDAT- 1992/12/01 00:00
MHDA- 1992/12/01 00:01
CRDT- 1992/12/01 00:00
PHST- 1992/12/01 00:00 [pubmed]
PHST- 1992/12/01 00:01 [medline]
PHST- 1992/12/01 00:00 [entrez]
AID - 0896-6273(92)90064-K [pii]
AID - 10.1016/0896-6273(92)90064-k [doi]
PST - ppublish
SO  - Neuron. 1992 Dec;9(6):1041-52. doi: 10.1016/0896-6273(92)90064-k.