PMID- 14636373
OWN - NLM
STAT- MEDLINE
DCOM- 20041202
LR  - 20191108
IS  - 1398-5647 (Print)
IS  - 1398-5647 (Linking)
VI  - 5
IP  - 6
DP  - 2003 Dec
TI  - Polymorphism of the brain-derived neurotrophic factor gene and performance on a 
      cognitive prefrontal test in bipolar patients.
PG  - 468-72
AB  - OBJECTIVES: The aim of the study was to test a possible association between the 
      Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene and 
      performance on a neurocognitive test, the Wisconsin Card Sorting Test (WCST), in 
      bipolar patients. METHODS: Fifty-four bipolar patients were studied, 18 male and 
      36 female, aged 18-72 (mean 46 years). The number of perseverative errors 
      (WCST-P), non-perseverative errors (WCST-NP), completed corrected categories 
      (WCST-CC), conceptual level responses (WCST-%CONC) and set to the first category 
      (WCST-1st CAT) were measured in relation to the Val66Met genotypes of BDNF. 
      RESULTS: The percentages of subjects with Val/Val, Val/Met and Met/Met genotypes 
      were respectively 81.5, 16.7 and 1.8%. Subjects with Val/Val and Val/Met 
      genotypes did not differ on clinical factors except for the age of onset of the 
      illness, which was earlier in Val/Val than Val/Met genotype (27 years versus 38 
      years). The performance in all domains of WCST was significantly better in 
      subjects with Val/Val BDNF genotype compared with Val/Met genotype. CONCLUSIONS: 
      The results suggest a role of BDNF in prefrontal cognitive function in bipolar 
      illness. The tests of prefrontal cognition may be considered as endophenotypic 
      markers in bipolar illness.
FAU - Rybakowski, Janusz K
AU  - Rybakowski JK
AD  - Department of Adult Psychiatry, University of Medical Sciences, Poznan, Poland. 
      rybakows@wlkp.top.pl
FAU - Borkowska, Alina
AU  - Borkowska A
FAU - Czerski, Piotr M
AU  - Czerski PM
FAU - Skibinska, Maria
AU  - Skibinska M
FAU - Hauser, Joanna
AU  - Hauser J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Bipolar Disord
JT  - Bipolar disorders
JID - 100883596
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Bipolar Disorder/blood/*genetics/psychology
MH  - Brain-Derived Neurotrophic Factor/blood/*genetics
MH  - Cognition
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Neuropsychological Tests
MH  - Poland
MH  - *Polymorphism, Genetic
MH  - Prefrontal Cortex/physiopathology
EDAT- 2003/11/26 05:00
MHDA- 2004/12/16 09:00
CRDT- 2003/11/26 05:00
PHST- 2003/11/26 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2003/11/26 05:00 [entrez]
AID - 071 [pii]
AID - 10.1046/j.1399-5618.2003.00071.x [doi]
PST - ppublish
SO  - Bipolar Disord. 2003 Dec;5(6):468-72. doi: 10.1046/j.1399-5618.2003.00071.x.