PMID- 14637224
OWN - NLM
STAT- MEDLINE
DCOM- 20040126
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 80
IP  - 2-3
DP  - 2003 Nov
TI  - Environmental enrichment: effects on stereotyped behavior and neurotrophin 
      levels.
PG  - 259-66
AB  - The present study evaluated whether environmental enrichment-related effects on 
      the development of stereotyped behavior in deer mice were associated with 
      alterations in neurotrophin levels. Deer mice were reared in enriched or standard 
      cage conditions for 60 days. The mice were then tested in automated photocell 
      detectors and classified as either stereotypic or nonstereotypic. This testing 
      paradigm yielded four behaviorally distinct groups: enriched stereotypic, 
      enriched nonstereotypic, standard cage stereotypic, and standard cage 
      nonstereotypic. The motor cortex, striatum, and hippocampus were dissected, and 
      the levels of brain-derived neurotrophin factor (BDNF) and nerve growth factor 
      (NGF) in each brain region were analyzed using Promega ELISA kits. There were no 
      differences in either NGF or BDNF in either the motor cortex or the hippocampus. 
      In the striatum, the enriched nonstereotypic mice exhibited significantly more 
      BDNF than the enriched stereotypic, the standard cage nonstereotypic, or the 
      standard cage stereotypic mice. There were no differences in NGF in the striatum. 
      These results provide evidence that the enrichment-related prevention of 
      stereotyped behavior in deer mice is associated with increased BDNF in the 
      striatum.
FAU - Turner, Cortney A
AU  - Turner CA
AD  - Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, 
      Ann Arbor, MI 48109, USA.
FAU - Lewis, Mark H
AU  - Lewis MH
LA  - eng
GR  - F31 MH065081/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/anatomy & histology/metabolism
MH  - Brain Chemistry
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - *Environment
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Female
MH  - Male
MH  - Mice
MH  - Nerve Growth Factor/*metabolism
MH  - Peromyscus
MH  - Sex Factors
MH  - Stereotyped Behavior/*physiology
EDAT- 2003/11/26 05:00
MHDA- 2004/01/27 05:00
CRDT- 2003/11/26 05:00
PHST- 2003/11/26 05:00 [pubmed]
PHST- 2004/01/27 05:00 [medline]
PHST- 2003/11/26 05:00 [entrez]
AID - S0031938403002701 [pii]
AID - 10.1016/j.physbeh.2003.07.008 [doi]
PST - ppublish
SO  - Physiol Behav. 2003 Nov;80(2-3):259-66. doi: 10.1016/j.physbeh.2003.07.008.