PMID- 14637240
OWN - NLM
STAT- MEDLINE
DCOM- 20040126
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 80
IP  - 2-3
DP  - 2003 Nov
TI  - Kissing reduces allergic skin wheal responses and plasma neurotrophin levels.
PG  - 395-8
AB  - The effect of kissing on allergen-induced skin wheal responses and plasma 
      neurotrophin levels were studied in 30 normal subjects, 30 patients with allergic 
      rhinitis (AR), and 30 patients with atopic dermatitis (AD). All of the patients 
      with AR or AD are allergic to house dust mite (HDM) and Japanese cedar pollen 
      (JCP). They are all Japanese and they do not kiss habitually. The subject kissed 
      freely during 30 min with their lover or spouse alone in a room with closed doors 
      while listening to soft music. Before and after kissing, skin prick tests were 
      performed using commercial HDM allergen, JCP allergen, as well as histamine and 
      control solution, and wheal responses were measured. Simultaneously, plasma 
      levels of neurotrophin, including nerve growth factor (NGF), brain-derived 
      neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and -4 (NT-4) were measured. 
      Kissing significantly reduced wheal responses induced by HDM and JCP, but not by 
      histamine, and decreased plasma levels of NGF, BDNF, NT-3, and NT-4 in patients 
      with AR or AD, while it failed to do so in normal subjects. These finding 
      indicate that kissing have some implication in the study of neuroimmunology in 
      allergic patients.
FAU - Kimata, Hajime
AU  - Kimata H
AD  - Department of Allergy, Ujitakeda Hospital, 24-1, Umonji, Uji, Kyoto 611-0021, 
      Japan. h-kimata@takedahp.or.jp
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Allergens)
RN  - 0 (Nerve Growth Factors)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Adult
MH  - Allergens
MH  - Case-Control Studies
MH  - Dermatitis, Atopic/*blood/immunology
MH  - Female
MH  - Histamine/metabolism
MH  - Humans
MH  - Lip/physiology
MH  - *Love
MH  - Male
MH  - Nerve Growth Factors/*blood
MH  - Rhinitis, Allergic, Perennial/*blood/immunology
MH  - Skin/*immunology
MH  - Skin Tests/methods
EDAT- 2003/11/26 05:00
MHDA- 2004/01/27 05:00
CRDT- 2003/11/26 05:00
PHST- 2003/11/26 05:00 [pubmed]
PHST- 2004/01/27 05:00 [medline]
PHST- 2003/11/26 05:00 [entrez]
AID - S0031938403002956 [pii]
AID - 10.1016/j.physbeh.2003.09.004 [doi]
PST - ppublish
SO  - Physiol Behav. 2003 Nov;80(2-3):395-8. doi: 10.1016/j.physbeh.2003.09.004.