PMID- 14637265
OWN - NLM
STAT- MEDLINE
DCOM- 20040714
LR  - 20190706
IS  - 0009-8981 (Print)
IS  - 0009-8981 (Linking)
VI  - 338
IP  - 1-2
DP  - 2003 Dec
TI  - Myoglobin stratifies short-term risk in acute major pulmonary embolism.
PG  - 53-6
AB  - BACKGROUND: Concentrations of cardiac troponins can be elevated in acute 
      pulmonary embolism (APE) indicating myocardial injury. Although concentration of 
      myoglobin (MYO) increases after myocardial damage, even before detectable rise of 
      cardiac troponin levels occurs, MYO was not evaluated in APE. Therefore, we 
      assessed prevalence and prognostic significance of myoglobin in major APE. 
      METHODS: We studied 46 patients (30 women, aged 61.9+/-17.8 years) with major APE 
      defined with right ventricular dilatation. On admission serum myoglobin, and 
      cardiac troponin T (cTnT) were measured. Serum MYO concentrations >58 ng/ml for 
      women, and >72 ng/ml for men were considered abnormal. CTnT>0.01 ng/ml was 
      regarded to indicate myocardial injury. RESULTS: MYO levels exceeding sex 
      specific norms were found in 21/46 (45.7%) of patients, while detectable cTnT was 
      found in 24/46 (52.1%) of patients. Seven patients died during hospitalization. 
      Elevated MYO significantly predicted in-hospital mortality (OR 25, 95% CI 
      1.3-474.2), while increased cTnT concentration did not affect the survival. Among 
      clinical and echocardiographic variables only older age indicated worse prognosis 
      (OR 1.6, 95% CI 1.06-2.41). CONCLUSIONS: Myoglobin levels are elevated in serum 
      on admission in almost half of patients with major APE. Elevated myoglobin level, 
      marker of myocardial injury, is a powerful predictor of increased risk of fatal 
      outcome in major pulmonary embolism.
FAU - Pruszczyk, Piotr
AU  - Pruszczyk P
AD  - Department of Internal Medicine and Hypertension, Medical University of Warsaw, 
      Banacha 1a, 02-097 Warsaw, Poland. piotr.pruszcyzyk@amwaw.edu.pl
FAU - Bochowicz, Anna
AU  - Bochowicz A
FAU - Kostrubiec, Maciej
AU  - Kostrubiec M
FAU - Torbicki, Adam
AU  - Torbicki A
FAU - Szulc, Marcin
AU  - Szulc M
FAU - Gurba, Hubert
AU  - Gurba H
FAU - Kuczynska, Krystyna
AU  - Kuczynska K
FAU - Berent, Hanna
AU  - Berent H
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Myoglobin)
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myoglobin/*blood
MH  - Odds Ratio
MH  - Prognosis
MH  - Pulmonary Embolism/*blood/*diagnosis/drug therapy
MH  - Risk
MH  - Sex Characteristics
MH  - Survival Rate
EDAT- 2003/11/26 05:00
MHDA- 2004/07/15 05:00
CRDT- 2003/11/26 05:00
PHST- 2003/11/26 05:00 [pubmed]
PHST- 2004/07/15 05:00 [medline]
PHST- 2003/11/26 05:00 [entrez]
AID - S000989810300411X [pii]
AID - 10.1016/j.cccn.2003.07.017 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2003 Dec;338(1-2):53-6. doi: 10.1016/j.cccn.2003.07.017.