PMID- 14638457
OWN - NASA
STAT- MEDLINE
DCOM- 20040129
LR  - 20081121
IS  - 1077-9248 (Print)
IS  - 1077-9248 (Linking)
VI  - 9
IP  - 2
DP  - 2002 Dec
TI  - Short-term hypergravity influences NGF and BDNF expression, and mast cell 
      distribution in the lungs and heart of adult male mice.
PG  - 29-38
AB  - In this study we investigate the effects of short-term hypergravity on lung and 
      heart neurotrophins and mast cell distribution. Our results showed that brain 
      derived-neurotrophic factor (BDNF) protein and mRNA expression are increased in 
      the lungs of mice exposed to hypergravity while in the heart hypergravity causes 
      a marked reduction in BDNF mRNA expression, and a decrease in BDNF protein. 
      Compared to controls, nerve growth factor (NGF) protein was expressed more in the 
      heart of rotated mice. These observations demonstrate that altered hypergravity 
      can affect, though differentially, the local expression of NGF and BDNF proteins 
      and their mRNAs in the lung and heart and indicates that short-term exposure to 
      hypergravity causes a marked increase in BDNF, but not in NGF in the lungs of 
      adult mice. Moreover, mast cells, which are NGF-producing cells and implicated in 
      cardiac and respiratory activity, increased in number in proximity to blood 
      vessels in the heart and in lung airway epithelium of rotated mice. This study 
      indicates that hypergravity influences cardiovascular and respiratory tissue and 
      suggests a neurotrophin involvement in the reaction to this environmental 
      exposure.
FAU - Antonelli, Alessia
AU  - Antonelli A
AD  - Istituto di Neurobiologia, Consiglio Nazionale delle Ricerche, Rome, Italy.
FAU - Santucci, Daniela
AU  - Santucci D
FAU - Amendola, Tiziana
AU  - Amendola T
FAU - Triaca, Viviana
AU  - Triaca V
FAU - Corazzi, Giulio
AU  - Corazzi G
FAU - Francia, Nadia
AU  - Francia N
FAU - Fiore, Marco
AU  - Fiore M
FAU - Alleva, Enrico
AU  - Alleva E
FAU - Aloe, Luigi
AU  - Aloe L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Gravit Physiol
JT  - Journal of gravitational physiology : a journal of the International Society for 
      Gravitational Physiology
JID - 9437868
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 9061-61-4 (Nerve Growth Factor)
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - *Hypergravity
MH  - Lung/cytology/*metabolism
MH  - Male
MH  - Mast Cells/*cytology/metabolism
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Myocardium/cytology/*metabolism
MH  - Nerve Growth Factor/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Rotation
MH  - Stress, Physiological/metabolism
OID - NASA: 00030058
GN  - NASA: Grant numbers: ASI, ASI-ARS-98-45.
EDAT- 2003/11/26 05:00
MHDA- 2004/01/30 05:00
CRDT- 2003/11/26 05:00
PHST- 2003/11/26 05:00 [pubmed]
PHST- 2004/01/30 05:00 [medline]
PHST- 2003/11/26 05:00 [entrez]
PST - ppublish
SO  - J Gravit Physiol. 2002 Dec;9(2):29-38.