PMID- 14638845
OWN - NLM
STAT- MEDLINE
DCOM- 20040116
LR  - 20181113
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 198
IP  - 11
DP  - 2003 Dec 1
TI  - Lymphotoxin is required for maintaining physiological levels of serum IgE that 
      minimizes Th1-mediated airway inflammation.
PG  - 1643-52
AB  - Although elevated levels of IgE in asthmatic patients are strongly associated 
      with lung infiltration by activated T helper (Th) 2 cells, the physiological role 
      of immunoglobulin E (IgE) in the airway remains largely undefined. 
      Lymphotoxin-deficient alpha (LTalpha-/-) mice exhibit increased airway 
      inflammation, paradoxically accompanied by diminished levels of IgE and reduced 
      airway hyperresponsiveness in response to both environmental and induced antigen 
      challenge. The severe lung inflammation in LTalpha-/- mice is Th1 in nature and 
      can be alleviated by IgE reconstitution. Conversely, depletion of IgE in 
      wild-type mice recapitulates the lung pathologies of LTalpha-/- mice. Therefore, 
      this work has revealed that lymphotoxin is essential for IgE production, and a 
      physiological role of IgE in the airway may consist of maintaining the balance of 
      Th1 and Th2 responses to prevent aberrant inflammation.
FAU - Kang, Hyung-Sik
AU  - Kang HS
AD  - Department of Pathology, The University of Chicago, Chicago, IL 60637, USA.
FAU - Blink, Sarah E
AU  - Blink SE
FAU - Chin, Robert K
AU  - Chin RK
FAU - Lee, Youjin
AU  - Lee Y
FAU - Kim, Oliver
AU  - Kim O
FAU - Weinstock, Joel
AU  - Weinstock J
FAU - Waldschmidt, Thomas
AU  - Waldschmidt T
FAU - Conrad, Daniel
AU  - Conrad D
FAU - Chen, Bohao
AU  - Chen B
FAU - Solway, Julian
AU  - Solway J
FAU - Sperling, Anne I
AU  - Sperling AI
FAU - Fu, Yang-Xin
AU  - Fu YX
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20031124
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Lymphotoxin-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Bronchial Hyperreactivity/*immunology
MH  - Bronchoalveolar Lavage Fluid
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Flow Cytometry
MH  - Immunoglobulin E/*blood/deficiency
MH  - Lymphotoxin-alpha/genetics/*physiology
MH  - Mice
MH  - Mice, Knockout
MH  - Respiratory Mechanics
MH  - Th1 Cells/*immunology
PMC - PMC2194142
EDAT- 2003/11/26 05:00
MHDA- 2004/01/17 05:00
PMCR- 2004/06/01
CRDT- 2003/11/26 05:00
PHST- 2003/11/26 05:00 [pubmed]
PHST- 2004/01/17 05:00 [medline]
PHST- 2003/11/26 05:00 [entrez]
PHST- 2004/06/01 00:00 [pmc-release]
AID - jem.20021784 [pii]
AID - 20021784 [pii]
AID - 10.1084/jem.20021784 [doi]
PST - ppublish
SO  - J Exp Med. 2003 Dec 1;198(11):1643-52. doi: 10.1084/jem.20021784. Epub 2003 Nov 
      24.