PMID- 14640947
OWN - NLM
STAT- MEDLINE
DCOM- 20040712
LR  - 20191026
IS  - 1471-2598 (Print)
IS  - 1471-2598 (Linking)
VI  - 3
IP  - 8
DP  - 2003 Dec
TI  - Haematopoietic cell transplantation in the treatment of sickle cell disease.
PG  - 1215-24
AB  - Allogeneic haematopoietic cell transplantation (HCT) is presently the only 
      treatment which offers the possibility of a cure for patients with sickle cell 
      disease (SCD). While approximately 84% of patients survive disease-free after 
      human leukocyte antigen (HLA)-identical sibling donor HCT, this therapy has 
      traditionally been reserved for patients who have suffered serious complications 
      due to the risk of transplant-related morbidity and mortality. Typically, these 
      sickle-related complications have included recurrent episodes of acute chest 
      syndrome, recurrent vaso-occlusive episodes and stroke. The future of HCT for 
      haemoglobinopathies undoubtedly will evolve as transplant-related complications 
      are reduced and as the process of selecting patients for HCT is refined.
FAU - Atkins, Robert C
AU  - Atkins RC
AD  - Children's Hospital and Research Center at Oakland, Blood and Marrow 
      Transplantation Program, 747 52nd Street, Oakland, CA 94609, USA.
FAU - Walters, Mark C
AU  - Walters MC
LA  - eng
GR  - HL 68091/HL/NHLBI NIH HHS/United States
GR  - HL 68177/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Expert Opin Biol Ther
JT  - Expert opinion on biological therapy
JID - 101125414
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Anemia, Sickle Cell/mortality/*therapy
MH  - Disease-Free Survival
MH  - HLA Antigens/chemistry
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - Hemoglobinopathies/therapy
MH  - Histocompatibility Testing
MH  - Humans
MH  - Time Factors
MH  - Tissue Donors
MH  - Treatment Outcome
RF  - 65
EDAT- 2003/12/04 05:00
MHDA- 2004/07/13 05:00
CRDT- 2003/12/04 05:00
PHST- 2003/12/04 05:00 [pubmed]
PHST- 2004/07/13 05:00 [medline]
PHST- 2003/12/04 05:00 [entrez]
AID - 10.1517/14712598.3.8.1215 [doi]
PST - ppublish
SO  - Expert Opin Biol Ther. 2003 Dec;3(8):1215-24. doi: 10.1517/14712598.3.8.1215.