PMID- 14642442
OWN - NLM
STAT- MEDLINE
DCOM- 20040120
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 353
IP  - 1
DP  - 2003 Dec 15
TI  - Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in Parkinson's 
      disease and age of onset.
PG  - 75-7
AB  - Given the implications with respect to neuronal survival and the decreased level 
      of the protein in the striatal region in Parkinson's disease (PD), brain-derived 
      neurotrophic factor (BDNF) may be a candidate gene conferring susceptibility to 
      PD. In a recent study of a Japanese population, a functional BDNF Val66Met 
      polymorphism was associated with PD, however, an analogous investigation of a 
      western population did not replicate this finding. In the present study of a 
      Chinese sample, we have investigated the associations between the BDNF 
      polymorphism and susceptibility to PD and PD onset age. The distribution of the 
      BDNF genotypes and alleles did not differ significantly comparing PD patients and 
      controls. Further, the onset age was not significantly different comparing the 
      three BDNF genotype groups. Thus, our negative findings suggest that it is 
      unlikely that the BDNF Val66Met polymorphism plays a major role in the 
      pathogenesis of PD in the Chinese population. Other BDNF genetic variants, and 
      the association of these variants with PD symptomatology or treatment response, 
      may merit further investigation.
FAU - Hong, Chen-Jee
AU  - Hong CJ
AD  - Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC
FAU - Liu, Hsiu-Chih
AU  - Liu HC
FAU - Liu, Tsung-Yun
AU  - Liu TY
FAU - Lin, Ching-Hua
AU  - Lin CH
FAU - Cheng, Chih-Ya
AU  - Cheng CY
FAU - Tsai, Shih-Jen
AU  - Tsai SJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - *Age of Onset
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - Parkinson Disease/*genetics
MH  - *Polymorphism, Genetic
MH  - Taiwan/ethnology
MH  - Valine/genetics
EDAT- 2003/12/04 05:00
MHDA- 2004/01/21 05:00
CRDT- 2003/12/04 05:00
PHST- 2003/12/04 05:00 [pubmed]
PHST- 2004/01/21 05:00 [medline]
PHST- 2003/12/04 05:00 [entrez]
AID - S0304394003010978 [pii]
AID - 10.1016/j.neulet.2003.09.009 [doi]
PST - ppublish
SO  - Neurosci Lett. 2003 Dec 15;353(1):75-7. doi: 10.1016/j.neulet.2003.09.009.