PMID- 14643080
OWN - NLM
STAT- MEDLINE
DCOM- 20040204
LR  - 20220227
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 54
IP  - 11
DP  - 2003 Dec 1
TI  - Automatic activation of the semantic network in schizophrenia: evidence from 
      event-related brain potentials.
PG  - 1134-48
AB  - BACKGROUND: Language disorder associated with schizophrenia might be due to 
      disturbances in both automatic activation and mechanisms of controlled attention. 
      The contribution of each process to semantic memory dysfunction has not been 
      determined for schizophrenia, and the semantic priming paradigm is well-suited 
      for addressing this question. In the present report, event-related potentials 
      (ERPs) elicited under conditions assumed to reveal automatic activation (short 
      prime-target interval and low proportion of related words) are compared directly 
      with ERPs elicited under conditions associated with controlled processing (long 
      prime-target interval and high proportion of related words). METHODS: Visual ERPs 
      were recorded during a lexical decision task, in which semantic relationship 
      (associated and unassociated words), expectancy (relatedness proportions), and 
      prime-target interval (250- and 850-msec inter-stimulus intervals [ISIs]) were 
      varied. Diagnosis and expectancy were between-subjects factors; semantic 
      relationship and ISI were repeated measures. The N400 priming effect (enhanced 
      negativity to unassociated words) was compared between 34 male normal control 
      subjects tested once and 37 male schizophrenia inpatients evaluated during their 
      participation in a double-blind haloperidol maintenance therapy and placebo 
      replacement protocol. RESULTS: The N400 priming effect for patients was 
      significantly reduced during both pharmacologic phases, compared with controls. 
      During haloperidol treatment, however, patients showed a significant N400 priming 
      effect over the anterior scalp region and additionally under the automatic 
      activation condition. The N400 priming effect was enhanced under the controlled 
      processing condition for control subjects; this effect was not observed for 
      patients. N400 amplitude elicited under the rapid presentation rate (250-msec 
      ISI) differed between medicated patients and controls; groups did not differ for 
      the 850-msec ISI. CONCLUSIONS: Findings suggest that automatic activation and 
      mechanisms of controlled attention are both disrupted during semantic memory 
      access for schizophrenia patients. Pharmacologic agents, such as haloperidol, 
      might enhance automatic activation of the semantic network in this patient 
      population, as indexed by the N400 component of the ERP.
FAU - Condray, Ruth
AU  - Condray R
AD  - Department of Psychiatry, Western Psychiatric Institute and Clinic, University of 
      Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
FAU - Siegle, Greg J
AU  - Siegle GJ
FAU - Cohen, Jonathan D
AU  - Cohen JD
FAU - van Kammen, Daniel P
AU  - van Kammen DP
FAU - Steinhauer, Stuart R
AU  - Steinhauer SR
LA  - eng
GR  - MH50631/MH/NIMH NIH HHS/United States
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/therapeutic use
MH  - Brain/*physiopathology
MH  - Case-Control Studies
MH  - Double-Blind Method
MH  - Evoked Potentials, Visual/*physiology
MH  - Humans
MH  - Male
MH  - Memory/physiology
MH  - Schizophrenia/diagnosis/drug therapy/*physiopathology
MH  - *Schizophrenic Psychology
MH  - *Semantics
EDAT- 2003/12/04 05:00
MHDA- 2004/02/05 05:00
CRDT- 2003/12/04 05:00
PHST- 2003/12/04 05:00 [pubmed]
PHST- 2004/02/05 05:00 [medline]
PHST- 2003/12/04 05:00 [entrez]
AID - S0006322303006991 [pii]
AID - 10.1016/s0006-3223(03)00699-1 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2003 Dec 1;54(11):1134-48. doi: 10.1016/s0006-3223(03)00699-1.