PMID- 14643272
OWN - NLM
STAT- MEDLINE
DCOM- 20040210
LR  - 20190513
IS  - 0195-668X (Print)
IS  - 0195-668X (Linking)
VI  - 24
IP  - 23
DP  - 2003 Dec
TI  - The angiotensin converting enzyme inhibitor trandolapril has neutral effect on 
      exercise tolerance or functional class in patients with myocardial infarction and 
      reduced left ventricular systolic function.
PG  - 2116-22
AB  - AIMS: To study the effect of angiotensin-converting enzyme (ACE) inhibitor 
      trandolapril on exercise tolerance time (ETT) and New York Heart Association 
      (NYHA) classification in patients with reduced left ventricular systolic 
      dysfunction (LVSD) after acute myocardial infarction (AMI). METHODS AND RESULTS: 
      The TRAndolapril Cardiac Evaluation (TRACE) was a randomized controlled study 
      designed to evaluate the effect of trandolapril on mortality in 1749 consecutive 
      Danish patients with LVSD after AMI. NYHA class was recorded every 3 months in 
      all patients. In a prospective sub-study, 254 patients underwent exercise 
      tolerance tests at 1, 3 and 12 months. The two treatment arms showed equal 
      improvement in NYHA class both in the entire and exclusively symptomatic 
      population over 4 years of follow-up (P=ns). ETT increased equally in both 
      treatment arms at 1, 3, 12 months (P=ns). A mean of 12mg/day of furosemide was 
      spared in trandolapril arm (P=0.001). CONCLUSIONS: Trandolapril had a mild 
      diuretic-sparing effect. These results emphasis the importance of explaining to 
      patients that ACE inhibitors provide protection against death and hospitalisation 
      for heart failure but do not have any significant effect upon symptoms.
FAU - Abdulla, Jawdat
AU  - Abdulla J
AD  - Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark. 
      jawab@dadlnet.dk
FAU - Burchardt, Hans
AU  - Burchardt H
FAU - Z Abildstrom, Steen
AU  - Z Abildstrom S
FAU - Kober, Lars
AU  - Kober L
FAU - Torp-Pedersen, Christian
AU  - Torp-Pedersen C
CN  - TRACE Study Group
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Indoles)
RN  - 1T0N3G9CRC (trandolapril)
SB  - IM
CIN - Eur Heart J. 2004 Mar;25(5):447-8; author reply 448. PMID: 15033260
MH  - Aged
MH  - Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
MH  - Drug Evaluation
MH  - Exercise Test
MH  - Exercise Tolerance/drug effects
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Indoles/*therapeutic use
MH  - Male
MH  - Myocardial Infarction/*drug therapy/physiopathology
MH  - Prospective Studies
MH  - Survival Analysis
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/*drug therapy/physiopathology
EDAT- 2003/12/04 05:00
MHDA- 2004/02/11 05:00
CRDT- 2003/12/04 05:00
PHST- 2003/12/04 05:00 [pubmed]
PHST- 2004/02/11 05:00 [medline]
PHST- 2003/12/04 05:00 [entrez]
AID - S0195668X03005761 [pii]
AID - 10.1016/j.ehj.2003.09.004 [doi]
PST - ppublish
SO  - Eur Heart J. 2003 Dec;24(23):2116-22. doi: 10.1016/j.ehj.2003.09.004.