PMID- 14644035
OWN - NLM
STAT- MEDLINE
DCOM- 20040322
LR  - 20220330
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 145
IP  - 1-2
DP  - 2003 Dec
TI  - Neurochemical sensitization associated with systemic administration of tumor 
      necrosis factor-alpha: adjuvant action in combination with bovine serum albumin.
PG  - 91-102
AB  - Tumor necrosis factor-alpha (TNF-alpha) provokes a time-dependent sensitization 
      of brain monoamine activity, plasma corticosterone activity and sickness 
      behavior, the latter being reminiscent of septic or anaphylactic shock. In this 
      investigation, bovine serum albumin (BSA) elicited similar corticosterone and 
      sickness profiles, whereas the monoamine changes were not observed. The 
      sensitization elicited by mTNF-alpha plus BSA was markedly greater than that 
      elicited by BSA alone. Carrier-free TNF-alpha promoted the sensitization of brain 
      monoamine activity, but not sickness or corticosterone. It is suggested that 
      mTNF-alpha acts as an adjuvant to the anaphylactic actions elicited by BSA, but 
      may provoke a sensitization of monoamine activity which is time-dependent and 
      varies across brain regions.
FAU - Anisman, Hymie
AU  - Anisman H
AD  - Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada K1S 5B6. 
      hanisman@ccs.carleton.ca
FAU - Turrin, Nicolas P
AU  - Turrin NP
FAU - Merali, Zul
AU  - Merali Z
FAU - Hayley, Shawn
AU  - Hayley S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Drug Carriers)
RN  - 0 (Drug Combinations)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 534-82-7 (Methoxyhydroxyphenylglycol)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adjuvants, Immunologic/*administration & dosage
MH  - Anaphylaxis/immunology/metabolism
MH  - Animals
MH  - Biogenic Monoamines/metabolism
MH  - Brain Chemistry/*immunology
MH  - Corticosterone/metabolism
MH  - Drug Administration Schedule
MH  - Drug Carriers
MH  - Drug Combinations
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - *Immunization/methods
MH  - Injections, Intraperitoneal
MH  - Male
MH  - Methoxyhydroxyphenylglycol/metabolism
MH  - Mice
MH  - Motor Activity/immunology
MH  - Restraint, Physical
MH  - Serum Albumin, Bovine/*administration & dosage/*immunology
MH  - Stress, Physiological/immunology/metabolism/physiopathology
MH  - Tumor Necrosis Factor-alpha/*administration & dosage
EDAT- 2003/12/04 05:00
MHDA- 2004/03/23 05:00
CRDT- 2003/12/04 05:00
PHST- 2003/12/04 05:00 [pubmed]
PHST- 2004/03/23 05:00 [medline]
PHST- 2003/12/04 05:00 [entrez]
AID - S016557280300393X [pii]
AID - 10.1016/j.jneuroim.2003.09.014 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2003 Dec;145(1-2):91-102. doi: 10.1016/j.jneuroim.2003.09.014.