PMID- 14644138
OWN - NLM
STAT- MEDLINE
DCOM- 20040206
LR  - 20191108
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 24
IP  - 12
DP  - 2003 Dec
TI  - Induction of tolerogenic DCs: 'you are what you eat'.
PG  - 646-51
AB  - Dendritic cells (DCs) take up antigens using antigen receptors that can be 
      divided into three major classes: C-type lectins, integrins and Fc receptors. 
      These receptors facilitate effective presentation of MHC-peptide complexes to T 
      cells, resulting in the induction of immune responses. However, we discuss recent 
      evidence that some receptors also cause induction of tolerance. Signaling motifs 
      within the receptors either block maturation of DCs or induce signals that render 
      DCs tolerogenic. These DCs then either induce regulatory T cells or cause 
      deletion of effector T cells, resulting in the induction of tolerance. Antigen 
      receptors expressed by DCs might therefore have an important role in the 
      induction and maintenance of peripheral tolerance.
FAU - Mahnke, Karsten
AU  - Mahnke K
AD  - Department of Dermatology, University of Mainz, Langenbeckstrasse 1, D-55101, 
      Mainz, Germany.
FAU - Knop, Juergen
AU  - Knop J
FAU - Enk, Alexander H
AU  - Enk AH
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
RN  - 0 (Receptors, Antigen)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - *Immune Tolerance
MH  - Models, Immunological
MH  - Receptors, Antigen/chemistry/*immunology
MH  - Signal Transduction/*immunology
RF  - 60
EDAT- 2003/12/03 05:00
MHDA- 2004/02/10 05:00
CRDT- 2003/12/03 05:00
PHST- 2003/12/03 05:00 [pubmed]
PHST- 2004/02/10 05:00 [medline]
PHST- 2003/12/03 05:00 [entrez]
AID - S1471490603003053 [pii]
AID - 10.1016/j.it.2003.09.012 [doi]
PST - ppublish
SO  - Trends Immunol. 2003 Dec;24(12):646-51. doi: 10.1016/j.it.2003.09.012.