PMID- 14644331
OWN - NLM
STAT- MEDLINE
DCOM- 20040121
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 544
IP  - 2-3
DP  - 2003 Nov
TI  - Formation of chromosome aberrations: insights from FISH.
PG  - 299-304
AB  - Most of the mutagenic and carcinogenic agents induce chromosome aberrations in 
      vivo and in vitro. Conventional solid staining (such as Giemsa) has been employed 
      to evaluate the frequencies and types of spontaneous and induced chromosomal 
      aberrations. Recently, molecular cytogenetic techniques such as fluorescence in 
      situ hybridization (FISH) using chromosome specific or chromosome region-specific 
      DNA libraries have become available, which have increased the resolution of the 
      detection of aberrations. This has lead to a better understanding on the 
      mechanisms of formation of chromosome aberrations, especially following treatment 
      with ionizing radiation. The present paper reviews briefly the results obtained 
      using FISH technique both from basic and applied studies.
FAU - Natarajan, A T
AU  - Natarajan AT
AD  - Department Toxicogenetics, Leiden University Medical Center, Wassenaarseweg 72, 
      2333 AL Leiden, The Netherlands. natarajan@lumc.nl
FAU - Boei, J J W A
AU  - Boei JJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Carcinogens)
RN  - 0 (Mutagens)
SB  - IM
MH  - Carcinogens/toxicity
MH  - Chromosome Aberrations/*drug effects/radiation effects
MH  - Chromosomes, Human/drug effects/genetics
MH  - Gene Library
MH  - Genome, Human
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Mutagens/toxicity
RF  - 25
EDAT- 2003/12/04 05:00
MHDA- 2004/01/22 05:00
CRDT- 2003/12/04 05:00
PHST- 2003/12/04 05:00 [pubmed]
PHST- 2004/01/22 05:00 [medline]
PHST- 2003/12/04 05:00 [entrez]
AID - S1383574203000978 [pii]
AID - 10.1016/j.mrrev.2003.09.005 [doi]
PST - ppublish
SO  - Mutat Res. 2003 Nov;544(2-3):299-304. doi: 10.1016/j.mrrev.2003.09.005.