PMID- 14644340
OWN - NLM
STAT- MEDLINE
DCOM- 20040121
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 544
IP  - 2-3
DP  - 2003 Nov
TI  - Genetic susceptibility to infection with human papillomavirus and development of 
      cervical cancer in women in Brazil.
PG  - 375-83
AB  - Human papillomavirus (HPV) is considered to be a necessary but not sufficient 
      cause for cervical cancer and, therefore, other factors contribute to the 
      carcinogenic process. A hereditary component for this neoplasia has been reported 
      and several studies indicate that genetic background of the host is important for 
      cervical cancer susceptibility. Among genetic factors that could participate in 
      the susceptibility to this tumor and disease outcome, polymorphic genes of the 
      major histocompatibility complex (MHC), as well as a particular polymorphism in 
      the p53 gene have been intensely investigated. From our analysis of 613 samples 
      in Brazil, we found evidence to indicate that different polymorphic human 
      leukocyte antigen (HLA) genes are involved in the clearance and maintenance of 
      HPV infection. In addition, the homozygous codon 72 p53-Arg gene allele is 
      associated with susceptibility to HPV-associated cervical carcinogenesis. 
      However, supportive and opposing data have been reported in different 
      populations. Therefore, international collaborative studies need to be conducted 
      to define the consistency of the associations described.
FAU - de Araujo Souza, Patricia Savio
AU  - de Araujo Souza PS
AD  - Ludwig Institute for Cancer Research, R. Prof. Antonio Prudente 109, 4 degrees 
      andar, 01509-010 Sao Paulo, SP, Brazil.
FAU - Villa, Luisa Lina
AU  - Villa LL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Brazil/epidemiology
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - HLA Antigens/immunology
MH  - Humans
MH  - *Papillomaviridae
MH  - Papillomavirus Infections/*complications
MH  - Risk Factors
MH  - Uterine Cervical Neoplasms/*epidemiology/*genetics/immunology
RF  - 52
EDAT- 2003/12/04 05:00
MHDA- 2004/01/22 05:00
CRDT- 2003/12/04 05:00
PHST- 2003/12/04 05:00 [pubmed]
PHST- 2004/01/22 05:00 [medline]
PHST- 2003/12/04 05:00 [entrez]
AID - S1383574203000942 [pii]
AID - 10.1016/j.mrrev.2003.06.013 [doi]
PST - ppublish
SO  - Mutat Res. 2003 Nov;544(2-3):375-83. doi: 10.1016/j.mrrev.2003.06.013.