PMID- 14645115
OWN - NLM
STAT- MEDLINE
DCOM- 20040323
LR  - 20071114
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 145
IP  - 3
DP  - 2004 Mar
TI  - Neonatal mice possessing an Sry transgene show a masculinized pattern of 
      progesterone receptor expression in the brain independent of sex chromosome 
      status.
PG  - 1046-9
AB  - To assess the relative roles of sex chromosome genes and gonadal steroid hormones 
      in producing sex differences in progesterone receptor (PR) expression in the 
      forebrain of neonatal mice, we used mice in which the Sry gene had been deleted 
      from the Y-chromosome and inserted as a transgene on an autosome in both XX and 
      XY genotypes. Levels of PR immunoreactivity (PRir) in the anteroventral 
      periventricular nucleus, the medial preoptic nucleus, and the ventromedial 
      nucleus were significantly higher in mice that possessed an Sry transgene 
      compared with mice that lacked an Sry transgene, regardless of their complement 
      of sex chromosomes (XX vs. XY). This result suggests that sexual differentiation 
      of PR expression in these regions is likely controlled mainly by gonadal 
      hormones, not by the genetic sex of the brain cells. No differences in PRir were 
      detected between wild-type XY mice with the Sry gene on the Y-chromosome and XY 
      mice with the Sry transgene, suggesting that testicular hormones produced in 
      these two genotypes have comparable effects on neural tissue.
FAU - Wagner, Christine K
AU  - Wagner CK
AD  - Department of Psychology, and Center for Neuroscience Research, University at 
      Albany-State University of New York, 12222, USA. cwagner@albany.edu
FAU - Xu, Jun
AU  - Xu J
FAU - Pfau, Jennifer L
AU  - Pfau JL
FAU - Quadros, Princy S
AU  - Quadros PS
FAU - De Vries, Geert J
AU  - De Vries GJ
FAU - Arnold, Arthur P
AU  - Arnold AP
LA  - eng
GR  - MH59268/MH/NIMH NIH HHS/United States
GR  - MH65874/MH/NIMH NIH HHS/United States
GR  - NS43196/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20031126
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Receptors, Progesterone)
RN  - 0 (Sex-Determining Region Y Protein)
RN  - 0 (Sry protein, mouse)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/growth & development/metabolism
MH  - Brain Chemistry/*genetics
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - Female
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Mice, Transgenic
MH  - *Nuclear Proteins
MH  - Receptors, Progesterone/*metabolism
MH  - Sex Characteristics
MH  - Sex-Determining Region Y Protein
MH  - *Transcription Factors
MH  - X Chromosome/*physiology
MH  - Y Chromosome/*physiology
EDAT- 2003/12/03 05:00
MHDA- 2004/03/24 05:00
CRDT- 2003/12/03 05:00
PHST- 2003/12/03 05:00 [pubmed]
PHST- 2004/03/24 05:00 [medline]
PHST- 2003/12/03 05:00 [entrez]
AID - en.2003-1219 [pii]
AID - 10.1210/en.2003-1219 [doi]
PST - ppublish
SO  - Endocrinology. 2004 Mar;145(3):1046-9. doi: 10.1210/en.2003-1219. Epub 2003 Nov 
      26.