PMID- 14645989
OWN - NLM
STAT- MEDLINE
DCOM- 20040129
LR  - 20191108
IS  - 0895-8696 (Print)
IS  - 0895-8696 (Linking)
VI  - 21
IP  - 3
DP  - 2003
TI  - Short-term sleep disturbance enhances brain-derived neurotrophic factor gene 
      expression in rat hippocampus by acting as internal stressor.
PG  - 223-32
AB  - Rats were subjected to nonselective sleep disturbance for short periods under 
      conditions designed to minimize the adverse influence of external stresses, such 
      as environmental conditions and restricted movement, and both brain-derived 
      neurotrophic factor (BDNF) protein and its mRNA levels in the brain were then 
      determined to investigate the influence of sleep disturbance itself on BDNF gene 
      expression. Total sleep duration was partially but significantly reduced by 
      disturbing the sleep/wake cycle for 1 and 2 h, gradually increased according to 
      the time of disturbance, then returned to control levels at 6 h after the 
      beginning of sleep disturbance. Under these conditions, the slight but 
      significant elevation of corticotrophin-releasing factor (CRF) mRNA levels in the 
      paraventricular nucleus (PVN) was observed at an early stage of the sleep 
      disturbance period. Sleep disturbance induced the elevation of both BDNF protein 
      and its mRNA levels in the hippocampus but not in the cerebellum or the 
      brainstem, and the elevated BDNF mRNA expression in the hippocampus returned 
      toward basal levels during the sleep recovery period when the rebound of sleep 
      duration was observed. These findings suggest the possibility that short-term 
      disturbance of the sleep/wake cycle and, hence, the partial reduction of non-REM 
      sleep duration, might exert a potential influence on neuronal and/or glial cells 
      as an internal stressor, resulting in the elevation of BDNF gene expression in 
      rat hippocampus.
FAU - Fujihara, Hiroaki
AU  - Fujihara H
AD  - Department of Integrative Physiology, Tokushima University School of Medicine, 
      Kuramoto, Tokushima 770-8503, Japan.
FAU - Sei, Hiroyoshi
AU  - Sei H
FAU - Morita, Yusuke
AU  - Morita Y
FAU - Ueta, Yoichi
AU  - Ueta Y
FAU - Morita, Kyoji
AU  - Morita K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Mol Neurosci
JT  - Journal of molecular neuroscience : MN
JID - 9002991
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Corticotropin-Releasing Hormone/genetics
MH  - Hippocampus/*metabolism
MH  - Hypothalamo-Hypophyseal System/metabolism
MH  - Male
MH  - Paraventricular Hypothalamic Nucleus/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Sleep Deprivation/*genetics
MH  - Sleep, REM/physiology
MH  - Stress, Physiological/genetics/*metabolism
MH  - Up-Regulation/*genetics
EDAT- 2003/12/04 05:00
MHDA- 2004/01/30 05:00
CRDT- 2003/12/04 05:00
PHST- 2003/07/30 00:00 [received]
PHST- 2003/08/30 00:00 [accepted]
PHST- 2003/12/04 05:00 [pubmed]
PHST- 2004/01/30 05:00 [medline]
PHST- 2003/12/04 05:00 [entrez]
AID - JMN:21:3:223 [pii]
AID - 10.1385/jmn:21:3:223 [doi]
PST - ppublish
SO  - J Mol Neurosci. 2003;21(3):223-32. doi: 10.1385/jmn:21:3:223.