PMID- 14646695 OWN - NLM STAT- MEDLINE DCOM- 20041208 LR - 20191026 IS - 0960-314X (Print) IS - 0960-314X (Linking) VI - 13 IP - 12 DP - 2003 Dec TI - ADRIS--The Adverse Drug Reactions Information Scheme. PG - 767-72 AB - Under the Adverse Drug Reactions Information Scheme (ADRIS) data and knowledge relevant to the etiology of adverse drug reactions (ADRs) such as chemical structure of parent compounds, metabolites, covalent adducts, nucleic acid and protein sequences, protein structures, pharmaco-, toxico- and enzyme kinetics, pharmaco- and toxicodynamics, protein interactions, molecular pathways and complexes, as well as toxicological and clinical outcomes, are collected and logically and semantically related. ADRIS reflects the ontological prerequisite for the creation of databases and knowledge discovery systems for the abstraction and visualization of theragenomic concepts. A final outcome is the prediction of ADRs based on a profound knowledge of drug function and the molecular basics for personalized drug safety and eventually, personalized medicine. CI - Copyright 2003 Lippincott Williams & Wilkins FAU - Hug, Hubert AU - Hug H AD - TheraSTrat AG, Allschwil, Switzerland. FAU - Bagatto, Dario AU - Bagatto D FAU - Dannecker, Robert AU - Dannecker R FAU - Schindler, Richard AU - Schindler R FAU - Horlacher, Oliver AU - Horlacher O FAU - Gut, Joseph AU - Gut J LA - eng PT - Journal Article PL - England TA - Pharmacogenetics JT - Pharmacogenetics JID - 9211735 SB - IM MH - *Adverse Drug Reaction Reporting Systems/trends MH - Data Collection MH - Database Management Systems EDAT- 2003/12/04 05:00 MHDA- 2004/12/16 09:00 CRDT- 2003/12/04 05:00 PHST- 2003/12/04 05:00 [pubmed] PHST- 2004/12/16 09:00 [medline] PHST- 2003/12/04 05:00 [entrez] AID - 10.1097/00008571-200312000-00007 [doi] PST - ppublish SO - Pharmacogenetics. 2003 Dec;13(12):767-72. doi: 10.1097/00008571-200312000-00007.