PMID- 14650578
OWN - NLM
STAT- MEDLINE
DCOM- 20040206
LR  - 20191210
IS  - 1343-4934 (Print)
IS  - 1343-4934 (Linking)
VI  - 45
IP  - 3
DP  - 2003 Sep
TI  - Cyclopiazonic acid discharges intracellular Ca2+ stores and stimulates Ca2+ 
      influx in cultured human gingival fibroblasts.
PG  - 139-44
AB  - The effect of cyclopiazonic acid (CPA) on changes in the intracellular free Ca2+ 
      concentration ([Ca2+]i) evoked by bradykinin (BK), histamine (HIST) and 
      thapsigargin (TG) was investigated in human gingival fibroblasts. CPA itself 
      dose-dependently stimulated [Ca2+]i responses in both the absence and presence of 
      extracellular Ca2+. Pretreatment with CPA (< 5 microM) enhanced the [Ca2+]i 
      responses evoked by 5 nM BK and 1 mM HIST. However, CPA-pretreatment depressed 
      the [Ca2+]i response evoked by 1 microM TG in a dose-dependent manner. Moreover, 
      CPA accelerated the Ca2+ influx caused by 5 nM BK and 1mM HIST, but did not alter 
      that caused by 1 microM TG. These results indicate that CPA discharges 
      intracellular Ca2+ stores, resulting in their depletion, and enhances Ca2+ influx 
      across the plasma membrane.
FAU - Matsumoto, Hiroko
AU  - Matsumoto H
AD  - Department of Pharmacology, Nihon University School of Dentistry at Matsudo, 
      Chiba 271-8587, Japan.
FAU - Takeuchi, Reiri
AU  - Takeuchi R
FAU - Arai, Takafumi
AU  - Arai T
FAU - Sato, Naoto
AU  - Sato N
FAU - Akimotot, Yoshiaki
AU  - Akimotot Y
FAU - Fujii, Akira
AU  - Fujii A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Oral Sci
JT  - Journal of oral science
JID - 9808942
RN  - 0 (Indoles)
RN  - 67526-95-8 (Thapsigargin)
RN  - 820484N8I3 (Histamine)
RN  - EC 7.2.2.10 (Calcium-Transporting ATPases)
RN  - S8TIM42R2W (Bradykinin)
RN  - SY7Q814VUP (Calcium)
RN  - X9TLY4580Z (cyclopiazonic acid)
SB  - IM
MH  - Bradykinin/pharmacology
MH  - Calcium/*metabolism
MH  - Calcium-Transporting ATPases/antagonists & inhibitors
MH  - Cells, Cultured
MH  - Fibroblasts/drug effects/metabolism
MH  - Gingiva/cytology/*drug effects/metabolism
MH  - Histamine/pharmacology
MH  - Humans
MH  - Indoles/*pharmacology
MH  - Thapsigargin/pharmacology
EDAT- 2003/12/03 05:00
MHDA- 2004/02/10 05:00
CRDT- 2003/12/03 05:00
PHST- 2003/12/03 05:00 [pubmed]
PHST- 2004/02/10 05:00 [medline]
PHST- 2003/12/03 05:00 [entrez]
AID - 10.2334/josnusd.45.139 [doi]
PST - ppublish
SO  - J Oral Sci. 2003 Sep;45(3):139-44. doi: 10.2334/josnusd.45.139.