PMID- 14651270
OWN - NLM
STAT- MEDLINE
DCOM- 20041116
LR  - 20240315
IS  - 1016-8478 (Print)
IS  - 1016-8478 (Linking)
VI  - 16
IP  - 2
DP  - 2003 Oct 31
TI  - Downregulation of voltage-gated potassium channel alpha gene expression by 
      axotomy and neurotrophins in rat dorsal root ganglia.
PG  - 256-9
AB  - Injury to peripheral nerves causes a neuropathic pain which is difficult to 
      relieve, but the underlying mechanism remains largely unknown. In previous 
      studies we reported that voltage-gated potassium (Kv) channel alpha genes are 
      downregulated in the dorsal root ganglia (DRG) following chronic constriction of 
      the sciatic nerve [Kim et al. (2002)], suggesting a relationship between 
      electrical abnormalities of the injured neurons and Kv gene expression. Here, we 
      examined expression of the Kv 1.2, 1.4, and 4.2 genes in the DRG following 
      transection of the sciatic nerve, and investigated the effect of nerve growth 
      factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) 
      on expression of those mRNAs, using the reverse transcription-polymerase chain 
      reaction. Expression of these mRNAs was reduced by axotomy and by exposure to 
      BDNF, and NT-3 treatment. However no significant change was detected following 
      NGF treatment. Our findings suggest that downregulation of Kv channel gene 
      expression in DRG neurons by neurotrophins may play an important role in 
      long-term changes of neuronal excitability following nerve injury.
FAU - Park, So Yun
AU  - Park SY
AD  - Department of Anatomy, School of Medicine, Kyungpook National University, Daegu 
      700-422, Korea.
FAU - Choi, Jun Young
AU  - Choi JY
FAU - Kim, Rae Uk
AU  - Kim RU
FAU - Lee, Young Sup
AU  - Lee YS
FAU - Cho, Hee Jung
AU  - Cho HJ
FAU - Kim, Dong Sun
AU  - Kim DS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cells
JT  - Molecules and cells
JID - 9610936
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Potassium Channels, Voltage-Gated)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Axotomy
MH  - Brain-Derived Neurotrophic Factor/pharmacology
MH  - Down-Regulation/*physiology
MH  - Ganglia, Spinal/*metabolism
MH  - Nerve Growth Factor/pharmacology
MH  - Nerve Growth Factors/*pharmacology
MH  - Neurons/*metabolism
MH  - Potassium Channels, Voltage-Gated/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sciatic Nerve/surgery
EDAT- 2003/12/04 05:00
MHDA- 2004/11/17 09:00
CRDT- 2003/12/04 05:00
PHST- 2003/12/04 05:00 [pubmed]
PHST- 2004/11/17 09:00 [medline]
PHST- 2003/12/04 05:00 [entrez]
AID - S1016-8478(23)13797-6 [pii]
PST - ppublish
SO  - Mol Cells. 2003 Oct 31;16(2):256-9.