PMID- 14651527
OWN - NLM
STAT- MEDLINE
DCOM- 20041115
LR  - 20190827
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 63
IP  - 1
DP  - 2004 Jan
TI  - TNF-alpha promoter polymorphisms and extended HLA and TNF-alpha haplotypes in 
      Koreans based on 100 families.
PG  - 75-9
AB  - We investigated five single-nucleotide polymorphism (SNP) sites of tumor necrosis 
      factor-alpha (TNF-alpha) promoter, the distribution of five-locus TNF-alpha 
      haplotypes, and extended human leukocyte antigen (HLA)/TNF-alpha haplotypes in 
      200 parents from 100 unrelated Korean families. TNF-alpha SNPs were typed using 
      polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) and 
      PCR restriction fragment length polymorphism (PCR-RFLP) methods. The frequencies 
      of -1031C, -863A, -857T, -308A, and -238A alleles were 0.185, 0.145, 0.140, 
      0.060, and 0.040, respectively. The allele frequencies in Koreans were similar to 
      those of Japanese. A total of five TNF-alpha haplotypes 
      (-1031/-863/-857/-308/-238) were detected in 196 parents: TCCGG (frequency 
      0.617), CACGG (0.143), TCTGG (0.143), TCCAG (0.061), and CCCGA (0.036). Five most 
      common extended HLA/TNF-alpha haplotypes (frequencies >0.020) accounted for 16% 
      (63/392) of the total haplotypes. A total of 223 HLA haplotypes and 239 
      HLA/TNF-alpha haplotypes were detected, indicating that most HLA haplotypes are 
      exclusively associated with particular TNF-alpha haplotypes.
FAU - Park, Y J
AU  - Park YJ
AD  - Department of Laboratory Medicine, Seoul National University College of Medicine, 
      Seoul, South Korea.
FAU - Park, H
AU  - Park H
FAU - Park, M H
AU  - Park MH
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Family
MH  - HLA Antigens/*genetics/immunology
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Korea
MH  - Linkage Disequilibrium/genetics
MH  - *Polymorphism, Single-Stranded Conformational
MH  - Promoter Regions, Genetic/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2003/12/04 05:00
MHDA- 2004/11/16 09:00
CRDT- 2003/12/04 05:00
PHST- 2003/12/04 05:00 [pubmed]
PHST- 2004/11/16 09:00 [medline]
PHST- 2003/12/04 05:00 [entrez]
AID - 148 [pii]
AID - 10.1111/j.1399-0039.2004.00148.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2004 Jan;63(1):75-9. doi: 10.1111/j.1399-0039.2004.00148.x.