PMID- 14651531
OWN - NLM
STAT- MEDLINE
DCOM- 20041115
LR  - 20190827
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 63
IP  - 1
DP  - 2004 Jan
TI  - Identification of two novel HLA class II alleles, DQB1*030503 and DRB1*0447.
PG  - 93-5
AB  - Two novel human leukocyte antigen (HLA) class II alleles have been identified in 
      routine typing of bone marrow donors for the Australian Bone Marrow Donor 
      Registry in Sydney, Australia. Sequence analysis of exon 2 of both the DQB1 and 
      DRB1 genes revealed the novel polymorphism. A silent substitution of G to A at 
      nucleotide position 210 has been identified for the DQB1*030503 allele when 
      compared to the closest matched allele, DQB1*030501. There is no associated amino 
      acid difference between the translated products of the two alleles. The second 
      new allele is a variant of the DRB1 gene. The DRB1*0447 allele was identified 
      with three nucleotide substitutions compared to the closest matched allele 
      DRB1*0436. There is a silent mutation at nucleotide position 303, G to C and two 
      substitutions at adjacent nucleotide positions 344 and 345, T to G and G to T, 
      respectively. The latter two substitutions result in an amino acid change from 
      valine to glycine at position 86, implicating a different specificity and 
      affinity of antigen binding.
FAU - Velickovic, Z M
AU  - Velickovic ZM
AD  - Molecular Genetics, Tissue Typing, Australian Red Cross Blood Service, University 
      of Sydney, Sydney, Australia. zvelickovic@arcbs.redcross.org.au
FAU - Hogbin, J P
AU  - Hogbin JP
FAU - Truong, J
AU  - Truong J
FAU - Jaafar, S
AU  - Jaafar S
FAU - Dunckley, H
AU  - Dunckley H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (DNA Primers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Alleles
MH  - Australia
MH  - Base Sequence
MH  - Bone Marrow Transplantation
MH  - DNA Primers/genetics
MH  - Exons/genetics
MH  - HLA Antigens/*genetics/immunology
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Molecular Sequence Data
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Single-Stranded Conformational
MH  - Sequence Alignment
EDAT- 2003/12/04 05:00
MHDA- 2004/11/16 09:00
CRDT- 2003/12/04 05:00
PHST- 2003/12/04 05:00 [pubmed]
PHST- 2004/11/16 09:00 [medline]
PHST- 2003/12/04 05:00 [entrez]
AID - 144 [pii]
AID - 10.1111/j.1399-0039.2004.00144.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2004 Jan;63(1):93-5. doi: 10.1111/j.1399-0039.2004.00144.x.