PMID- 14653204
OWN - NLM
STAT- MEDLINE
DCOM- 20040224
LR  - 20151119
IS  - 0047-1860 (Print)
IS  - 0047-1860 (Linking)
VI  - 51
IP  - 10
DP  - 2003 Oct
TI  - [New diagnostic tests for rheumatoid arthritis].
PG  - 1030-5
AB  - Rheumatoid factor(RF) is one item in the classification criteria for rheumatoid 
      arthritis(RA), with a tolerable sensitivity of 69.3% for RA but low specificity 
      against other rheumatic diseases(76.4%). Anti-agalactosyl IgG antibody(CARF) 
      showed a slightly higher sensitivity(72.0%) but the specificity was even 
      lower(67.9%). Anti-cyclic citrullinated peptide antibody(anti-CCP), a new 
      diagnostic test for RA, demonstrated higher sensitivity(76.0%) and 
      specificity(91.5%), and the ROC analysis revealed the marked superiority of 
      anti-CCP to other markers(i.e. RF, CARF, and IgG-RF). Matrix metalloproteinase-3 
      (MMP-3) showed a significantly positive correlation with CRP, suggesting it might 
      be more useful for evaluation of RA activity and prediction of the prognosis of 
      joint destruction. On the contrary, two combination assays, "MMP-3 or CARF" and 
      "MMP-3 or anti-CCP", showed the highest sensitivity(86.7%) for RA. Similarly, in 
      early RA the sensitivities of CARF, MMP-3 and anti-CCP were lower than in 
      RA(66.7%, 66.7% and 58.3%, respectively), but the sensitivities of combination 
      assays "MMP-3 or CARF" and "MMP-3 or anti-CCP" were 91.7% and 83.3%, 
      respectively. Thus, we concluded that these combination assays are useful in the 
      diagnosis of RA and detection of early RA.
FAU - Hayashi, Nobuhide
AU  - Hayashi N
AD  - Department of Clinical Laboratory, Kobe University Hospital, Kobe, Hyogo 
      650-0017.
FAU - Kumagai, Shunichi
AU  - Kumagai S
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Rinsho Byori
JT  - Rinsho byori. The Japanese journal of clinical pathology
JID - 2984781R
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin G)
RN  - 0 (agalactosyl IGG)
RN  - 29VT07BGDA (Citrulline)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Arthritis, Rheumatoid/*diagnosis
MH  - Autoantibodies/*blood
MH  - Biomarkers/blood
MH  - Citrulline/immunology
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Matrix Metalloproteinase 3/blood
MH  - ROC Curve
MH  - Sensitivity and Specificity
RF  - 18
EDAT- 2003/12/05 05:00
MHDA- 2004/02/26 05:00
CRDT- 2003/12/05 05:00
PHST- 2003/12/05 05:00 [pubmed]
PHST- 2004/02/26 05:00 [medline]
PHST- 2003/12/05 05:00 [entrez]
PST - ppublish
SO  - Rinsho Byori. 2003 Oct;51(10):1030-5.