PMID- 14653396
OWN - NLM
STAT- MEDLINE
DCOM- 20040114
LR  - 20131121
IS  - 0022-3492 (Print)
IS  - 0022-3492 (Linking)
VI  - 74
IP  - 10
DP  - 2003 Oct
TI  - Associations of periodontal status with general health conditions and serum 
      antibody titers for Porphyromonas gingivalis and Actinobacillus 
      actinomycetemcomitans.
PG  - 1491-7
AB  - BACKGROUND: The purpose of the present study was to evaluate associations of 
      periodontal status with general health conditions and with serum antibody titers 
      for Porphyromonas gingivalis (Pg) and Actinobacillus actinomycetemcomitans (Aa) 
      in a Japanese population. METHODS: Subjects (1,314) aged 40 years or older were 
      recruited for the study. Their periodontal status was evaluated using the 
      community periodontal index of treatment needs (CPITN). Records from general 
      health examinations were used for the present analyses, including data on age, 
      gender, body mass index, systolic and diastolic blood pressure (SBP/DBP); levels 
      of serum alkaline phosphatase, total cholesterol, high-density lipoprotein 
      cholesterol, triglyceride, fasting blood glucose, and C-reactive protein (CRP); 
      counts of white blood cells (WBC) and platelets; smoking habit; and 
      electrocardiogram recordings. Serum IgG antibody titers for Pg fimbrial antigens 
      (IgG.Pg.Fim.), Pg whole-cell antigens (IgG.Pg.whol.), and Aa whole-cell antigens 
      (IgG.Aa.whol.) were determined using enzyme-linked immunosorbent assay. The 
      subjects were divided, according to their maximum CPITN codes, into four 
      periodontal groups: max.CPITN-0/1/2, -3, -4, or -MS (missing sextant). RESULTS: 
      Multivariable logistic regression analyses revealed significant associations of 
      the max.CPITN-4 subjects who were males (odds ratio, OR: 2.03) or smokers (OR: 
      1.73), or who had high diastolic blood pressure (OR: 1.27), high WBC (OR: 1.24), 
      high serum CRP level (OR: 2.39) and high serum IgG.Pg.Fim. (OR: 1.17), 
      IgG.Pg.whol. (OR:1.54), and IgG.Aa.whol. (OR: 1.19) titers. CONCLUSION: 
      Significant associations between periodontal status and several health conditions 
      were found in the adult population examined, including gender, smoking habit, 
      diastolic blood pressure, white blood cell counts, C-reactive protein, and serum 
      IgG antibodies to P. gingivalis fimbriae, IgG P. gingivalis whole cell, and IgG 
      A. actinomycetemcomitans whole cell titers.
FAU - Furuichi, Yasushi
AU  - Furuichi Y
AD  - Department of Periodontology, Kagoshima University Dental School, Sakuragaoka, 
      Kagoshima, Japan. yasushif@dentc.hal.kagoshima-u.ac.jp
FAU - Shimotsu, Akihiro
AU  - Shimotsu A
FAU - Ito, Hiroo
AU  - Ito H
FAU - Namariyama, Yukari
AU  - Namariyama Y
FAU - Yotsumoto, Yukiharu
AU  - Yotsumoto Y
FAU - Hino, Youichi
AU  - Hino Y
FAU - Mishige, Yukie
AU  - Mishige Y
FAU - Inoue, Masakazu
AU  - Inoue M
FAU - Izumi, Yuichi
AU  - Izumi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Antibodies, Bacterial)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aggregatibacter actinomycetemcomitans/immunology
MH  - Analysis of Variance
MH  - Antibodies, Bacterial/blood
MH  - Blood Pressure
MH  - C-Reactive Protein/analysis
MH  - Chi-Square Distribution
MH  - Female
MH  - *Health Status
MH  - Humans
MH  - Leukocyte Count
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Periodontal Diseases/*blood/*microbiology
MH  - Periodontal Index
MH  - Porphyromonas gingivalis/immunology
MH  - Smoking/blood
EDAT- 2003/12/05 05:00
MHDA- 2004/01/15 05:00
CRDT- 2003/12/05 05:00
PHST- 2003/12/05 05:00 [pubmed]
PHST- 2004/01/15 05:00 [medline]
PHST- 2003/12/05 05:00 [entrez]
AID - 10.1902/jop.2003.74.10.1491 [doi]
PST - ppublish
SO  - J Periodontol. 2003 Oct;74(10):1491-7. doi: 10.1902/jop.2003.74.10.1491.