PMID- 14653768
OWN - NLM
STAT- MEDLINE
DCOM- 20040227
LR  - 20131121
IS  - 1089-5159 (Print)
IS  - 1089-5159 (Linking)
VI  - 8
IP  - 4
DP  - 2003 Nov
TI  - Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and 
      therapeutic value in major depression.
PG  - 410-25
AB  - Omega-3 fatty acids have been the subject of volumes of international research, 
      the results of which indicate these substances may have therapeutic value in a 
      number of medical conditions. An emerging area of research is examining the 
      neurobehavioral aspects of omega-3 fatty acids (alpha-linolenic, 
      eicosapentaenoic, docosahexaenoic) and the critical role of these essential fats 
      in the functioning of the central nervous system. Investigations have linked 
      omega-3 fatty acids to a number of neuropsychiatric disorders, including 
      depression. The purpose of this article is to examine the possible mechanisms of 
      action and potential clinical value of omega-3 fatty acids in major depression. A 
      novel mechanism involving omega-3 modulation of cAMP response element binding 
      protein (CREB) and brain-derived neurotrophic factor (BDNF) is proposed.
FAU - Logan, Alan C
AU  - Logan AC
AD  - CAM Research Consulting, 13 Stonewall Court, Mahwah New Jersey 07430, USA. 
      aclnd@cfs-fm.org
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Altern Med Rev
JT  - Alternative medicine review : a journal of clinical therapeutic
JID - 9705340
RN  - 0 (Antidepressive Agents)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0RBV727H71 (alpha-Linolenic Acid)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
MH  - Antidepressive Agents/therapeutic use
MH  - Central Nervous System/physiology
MH  - Depressive Disorder, Major/*blood/epidemiology/etiology
MH  - Docosahexaenoic Acids/therapeutic use
MH  - Eicosapentaenoic Acid
MH  - Fatty Acids, Omega-3/*blood/therapeutic use
MH  - Fatty Acids, Unsaturated/therapeutic use
MH  - Humans
MH  - alpha-Linolenic Acid/therapeutic use
RF  - 117
EDAT- 2003/12/05 05:00
MHDA- 2004/02/28 05:00
CRDT- 2003/12/05 05:00
PHST- 2003/12/05 05:00 [pubmed]
PHST- 2004/02/28 05:00 [medline]
PHST- 2003/12/05 05:00 [entrez]
PST - ppublish
SO  - Altern Med Rev. 2003 Nov;8(4):410-25.