PMID- 14654242
OWN - NLM
STAT- MEDLINE
DCOM- 20040121
LR  - 20190610
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1630
IP  - 2-3
DP  - 2003 Nov 30
TI  - Genomic organization, promoter, amino acid sequence, chromosomal localization, 
      and expression of the human gene for CORS-26 (collagenous repeat-containing 
      sequence of 26-kDa protein).
PG  - 123-9
AB  - The murine gene for CORS-26 is located on mouse chromosome 15A2 and its 
      expression has been reported to be restricted to fibroblasts, cartilage and 
      kidney. Here, the complete genomic organization of the corresponding human 
      CORS-26 gene with exon/intron boundaries and exon-specific primer combinations is 
      presented. Additionally, a 1.2 kb fragment of the TATA box-containing promoter 
      region was cloned and analyzed for putative transcription factor binding sites. 
      The deduced amino acid sequence is presented completely. Northern blot analysis 
      using a human multiple-tissue cDNA panel demonstrated expression of human CORS-26 
      mRNA in colon and small intestine. Additionally, RT-PCR analysis revealed 
      expression of CORS-26 mRNA in placenta, fibroblasts and white adipose tissue. The 
      chromosomal localization of the human CORS-26 gene was mapped to human chromosome 
      5p by fluorescence in situ hybridization (FISH). In humans, chromosomal 
      imbalances on chromosome 5p were reported to be involved in the pathogenesis of 
      osteosarcoma. Therefore, a human bone tumor cDNA panel was investigated and a 
      strong CORS-26 mRNA expression was found in osteosarcoma, chondroblastoma and 
      giant cell tumor. The present data provide the basis for further investigation of 
      CORS-26 gene regulation in the context of mesenchymal tissue development and in 
      the pathogenesis of bone or skeletal disease.
FAU - Schaffler, A
AU  - Schaffler A
AD  - Department of Internal Medicine I, University of Regensburg, Germany. 
      andreas.schaeffler@klinik.uni-regensburg.de
FAU - Ehling, A
AU  - Ehling A
FAU - Neumann, E
AU  - Neumann E
FAU - Herfarth, H
AU  - Herfarth H
FAU - Paul, G
AU  - Paul G
FAU - Tarner, I
AU  - Tarner I
FAU - Gay, S
AU  - Gay S
FAU - Scholmerich, J
AU  - Scholmerich J
FAU - Muller-Ladner, U
AU  - Muller-Ladner U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Adipokines)
RN  - 0 (CORS26 protein, mouse)
RN  - 0 (Proteins)
SB  - IM
MH  - Adipokines
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Molecular Sequence Data
MH  - Promoter Regions, Genetic
MH  - Protein Biosynthesis
MH  - Proteins/*genetics
MH  - Sequence Analysis, DNA
EDAT- 2003/12/05 05:00
MHDA- 2004/01/22 05:00
CRDT- 2003/12/05 05:00
PHST- 2003/12/05 05:00 [pubmed]
PHST- 2004/01/22 05:00 [medline]
PHST- 2003/12/05 05:00 [entrez]
AID - S0167478103001830 [pii]
AID - 10.1016/j.bbaexp.2003.08.013 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2003 Nov 30;1630(2-3):123-9. doi: 
      10.1016/j.bbaexp.2003.08.013.