PMID- 14654461
OWN - NLM
STAT- MEDLINE
DCOM- 20040604
LR  - 20190513
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 14
IP  - 1
DP  - 2004 Jan
TI  - Involvement of tumor necrosis factor alpha in hippocampal development and 
      function.
PG  - 97-105
AB  - Tumor necrosis factor alpha (TNFalpha) is a cytokine produced mainly by cells of 
      the immune system. It is also expressed by brain neurons and glia. The 
      physiological role of TNFalpha in the brain is not yet fully clear. Using 
      TNFalpha-deficient mice, we have examined its role in hippocampal development and 
      function. We report here that TNFalpha is involved in the regulation of 
      morphological development in the hippocampus. TNFalpha-deficient mice exhibited 
      an accelerated maturation of the dentate gyrus region and smaller dendritic trees 
      in CA1 and CA3 regions in young mouse. In addition to its involvement in 
      hippocampal morphogenesis, TNFalpha deficiency specifically improved performance 
      of affected mice in behavioral tasks related to spatial memory. Moreover, lack of 
      TNFalpha increased the expression of nerve growth factor (NGF), but not 
      brain-derived neurotrophic factor (BDNF), following performance of the learning 
      task. Our results suggest that TNFalpha actively influences hippocampal 
      development and function. In adult mice, TNFalpha may interfere with memory 
      consolidation, perhaps by regulating NGF levels.
FAU - Golan, H
AU  - Golan H
AD  - Department of Developmental Molecular Genetics, Faculty of Health Sciences, Ben 
      Gurion University, Beer-Sheva, Israel 84105. havag@bgumail.bgu.ac.il
FAU - Levav, T
AU  - Levav T
FAU - Mendelsohn, A
AU  - Mendelsohn A
FAU - Huleihel, M
AU  - Huleihel M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Dendrites/physiology
MH  - Dentate Gyrus/physiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Hippocampus/*growth & development/physiology
MH  - Immunohistochemistry
MH  - Maze Learning/physiology
MH  - Memory/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Motor Activity/physiology
MH  - Nerve Growth Factor/metabolism
MH  - Phenotype
MH  - Pyramidal Cells/physiology
MH  - Reflex/physiology
MH  - Tumor Necrosis Factor-alpha/genetics/*physiology
EDAT- 2003/12/05 05:00
MHDA- 2004/06/05 05:00
CRDT- 2003/12/05 05:00
PHST- 2003/12/05 05:00 [pubmed]
PHST- 2004/06/05 05:00 [medline]
PHST- 2003/12/05 05:00 [entrez]
AID - 10.1093/cercor/bhg108 [doi]
PST - ppublish
SO  - Cereb Cortex. 2004 Jan;14(1):97-105. doi: 10.1093/cercor/bhg108.