PMID- 14656748
OWN - NLM
STAT- MEDLINE
DCOM- 20040413
LR  - 20111117
IS  - 1073-449X (Print)
IS  - 1073-449X (Linking)
VI  - 169
IP  - 6
DP  - 2004 Mar 15
TI  - Human leukocyte antigen class I alleles and the disease course in sarcoidosis 
      patients.
PG  - 696-702
AB  - Several lines of evidence suggest a genetic predisposition to sarcoidosis, and 
      strong associations have been shown with the major histocompatibility complex 
      gene complex. In this study on Scandinavian sarcoidosis patients, we investigated 
      any influence on the outcome of disease by human leukocyte antigen (HLA) class I 
      alleles alone and in combination with selected class II alleles. HLA-B*07 
      independently increased the risk for persistent sarcoidosis (odds ratio [OR], 
      1.9; 95% confidence interval [CI], 1.0-3.7), as well as for resolving disease 
      (OR, 2.7; CI, 1.1-6.2), suggesting an influence on factors common to both forms 
      of sarcoidosis. The common allele combination A*03, B*07, DRB1*15 was most 
      strongly associated with persistent disease (OR, 4.7; CI, 2.2-10.2) and was found 
      in 25.3% of patients with persistent disease versus 7.1% of healthy control 
      subjects. HLA-B*08 tended to increase separately the risk for resolving disease 
      (OR, 2.4; CI, 0.7-8.0), as well as for persistent disease (OR, 2.2; CI, 0.8-6.1). 
      Other HLA class I associations were mainly secondary to their linkages to DRB1*03 
      and DRB1*15, respectively. The influence of HLA class I alleles on sarcoidosis 
      thus seems more pronounced than previously thought, and both HLA class I and 
      class II should be relevant to evaluate in the clinical management of sarcoidosis 
      patients.
FAU - Grunewald, Johan
AU  - Grunewald J
AD  - Department of Medicine, Division of Respiratory Medicine, Karolinska Hospital, 
      Stockholm, Sweden. johan.grunewald@medks.ki.se
FAU - Eklund, Anders
AU  - Eklund A
FAU - Olerup, Olle
AU  - Olerup O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20031204
PL  - United States
TA  - Am J Respir Crit Care Med
JT  - American journal of respiratory and critical care medicine
JID - 9421642
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
CIN - Am J Respir Crit Care Med. 2004 Mar 15;169(6):665-6. PMID: 15003948
MH  - Adult
MH  - CD4-CD8 Ratio
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Respiratory Function Tests
MH  - Sarcoidosis, Pulmonary/*genetics/*immunology/therapy
MH  - Treatment Outcome
EDAT- 2003/12/06 05:00
MHDA- 2004/04/14 05:00
CRDT- 2003/12/06 05:00
PHST- 2003/12/06 05:00 [pubmed]
PHST- 2004/04/14 05:00 [medline]
PHST- 2003/12/06 05:00 [entrez]
AID - 200303-459OC [pii]
AID - 10.1164/rccm.200303-459OC [doi]
PST - ppublish
SO  - Am J Respir Crit Care Med. 2004 Mar 15;169(6):696-702. doi: 
      10.1164/rccm.200303-459OC. Epub 2003 Dec 4.