PMID- 14656893
OWN - NLM
STAT- MEDLINE
DCOM- 20040511
LR  - 20210206
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 103
IP  - 7
DP  - 2004 Apr 1
TI  - Possible link between unique chemokine and homing receptor expression at 
      diagnosis and relapse location in a patient with childhood T-ALL.
PG  - 2806-8
AB  - Childhood acute lymphoblastic leukemia (ALL) is often associated with 
      extramedullary infiltration by leukemic cells at diagnosis or at relapse. To 
      understand the mechanisms behind the dissemination of T-cell ALL (T-ALL) cells 
      this study investigated the homing receptor expression on the blast cells of 11 
      pediatric T-ALL patients at diagnosis. One patient revealed a unique profile with 
      high expression of the chemokine receptor CCR9 and the integrin CD103 on the 
      T-ALL cells. Both of these molecules are specifically associated with homing to 
      the gut. This finding was clinically significant as the patient later suffered a 
      relapse that was confined to the gut. Immunohistochemistry revealed that the 
      leukemic cells in the gut still expressed CCR9 and colocalized with a high 
      expression of the CCR9 ligand, CCL25. These findings suggest that the original 
      expression of CCR9 and CD103 on the leukemic cells contributed to the relapse 
      location in the gut of this patient.
FAU - Annels, Nicola E
AU  - Annels NE
AD  - Department of Paediatrics, Division of Immunology, Haematology, Oncology, Bone 
      Marrow Transplantation and Autoimmune Diseases, Leiden University Medical Center, 
      The Netherlands. n.e.annels@lumc.nl
FAU - Willemze, Annemieke J
AU  - Willemze AJ
FAU - van der Velden, Vincent H J
AU  - van der Velden VH
FAU - Faaij, Claudia M J M
AU  - Faaij CM
FAU - van Wering, Elisabeth
AU  - van Wering E
FAU - Sie-Go, Daisy M D S
AU  - Sie-Go DM
FAU - Egeler, R Maarten
AU  - Egeler RM
FAU - van Tol, Maarten J D
AU  - van Tol MJ
FAU - Revesz, Tom
AU  - Revesz T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20031204
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Receptors, Lymphocyte Homing)
SB  - IM
MH  - Calcium Signaling
MH  - Child
MH  - Humans
MH  - Leukemia, Myeloid, Acute/pathology
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis/pathology
MH  - Receptors, Chemokine/*analysis
MH  - Receptors, Lymphocyte Homing/*analysis
MH  - Recurrence
EDAT- 2003/12/06 05:00
MHDA- 2004/05/12 05:00
CRDT- 2003/12/06 05:00
PHST- 2003/12/06 05:00 [pubmed]
PHST- 2004/05/12 05:00 [medline]
PHST- 2003/12/06 05:00 [entrez]
AID - S0006-4971(20)43896-0 [pii]
AID - 10.1182/blood-2003-06-1812 [doi]
PST - ppublish
SO  - Blood. 2004 Apr 1;103(7):2806-8. doi: 10.1182/blood-2003-06-1812. Epub 2003 Dec 
      4.