PMID- 14658190
OWN - NLM
STAT- MEDLINE
DCOM- 20040722
LR  - 20140625
VI  - 17
IP  - 9
DP  - 2003 Sep
TI  - [The study on the expression of tumor-suppressor gene p15 and Rb in laryngeal 
      squamous cell carcinomas].
PG  - 543-4
AB  - OBJECTIVE: To study the clinical significance of p15 and Rb protein expressions 
      in laryngeal squamous cell carcinomas (LSCC). METHOD: p15 and Rb proteins were 
      examined with immunohistochemical SABC method in the paraffin-embedded specimens 
      of 45 cases with LSCC and 15 cases of laryngeal normal or proliferative mucosas 
      of larynx as a contrast. RESULT: The positive rate of p15 protein in the cases of 
      LSCC is 48.9%, while the positive rate in the other group is 100%. The difference 
      is significant. The positive rate of p15 protein is 66.7% in the group of LSCC 
      during 0-II phases, and in the other group of LSCC during III-IV phases, the 
      positive rate is 33.3%. The difference is significant. The positive rate of Rb 
      protein in the cases of LSCC is 88.9%, the positive rate in the other group as a 
      contrast is 93.3%, the difference between two groups isn't significant. Analyzed 
      by chi-square test, p15 protein expressions don't correlate with Rb protein 
      expressions in the cases of LSCC. Rb protein expressed apparently positiveness in 
      the basal cells and adjacent stratum spinosum cells of laryngeal stratified 
      squamous epithelium, while p15 protein expressed apparently positiveness in the 
      distant stratum spinosum cells and stratum granulosum cells. CONCLUSION: 
      Tumor-suppressor gene p15 may play an important role in the genesis and 
      development of LSCC. The analysis of p15 protein expression may provide evidence 
      for the therapeutics and evaluate prognosis of LSCC. p15 and Rb proteins aren't 
      parallel in each stratum of the laryngeal normal or proliferative stratified 
      squamous epithelium. p15 protein plays an important role in cell proliferation.
FAU - Wen, Shuxin
AU  - Wen S
AD  - Department of Otolaryngology, First Hospital of Shanxi Medical University, 
      Taiyuan 030001.
FAU - Wang, Binquan
AU  - Wang B
FAU - Chen, Yanqiu
AU  - Chen Y
FAU - Huang-Fu, Hui
AU  - Huang-Fu H
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (Retinoblastoma Protein)
SB  - IM
MH  - Carcinoma, Squamous Cell/chemistry/*genetics
MH  - Cell Cycle
MH  - Cyclin-Dependent Kinase Inhibitor p16/*biosynthesis/genetics
MH  - Female
MH  - Genes, Tumor Suppressor
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/chemistry/*genetics
MH  - Male
MH  - Retinoblastoma Protein/*biosynthesis/genetics
EDAT- 2003/12/09 05:00
MHDA- 2004/07/23 05:00
CRDT- 2003/12/09 05:00
PHST- 2003/12/09 05:00 [pubmed]
PHST- 2004/07/23 05:00 [medline]
PHST- 2003/12/09 05:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2003 Sep;17(9):543-4.