PMID- 14658597
OWN - NLM
STAT- MEDLINE
DCOM- 20040317
LR  - 20221207
IS  - 0392-2936 (Print)
IS  - 0392-2936 (Linking)
VI  - 24
IP  - 6
DP  - 2003
TI  - The triage of squamous cell abnormalities of cervical cytology by human papilloma 
      virus screening.
PG  - 535-8
AB  - OBJECTIVE: The aim of the study was to determine the presence of human papilloma 
      virus (HPV) infection in cervical swabs by the use of the Digene Hybrid Capture 
      assay in a cohort of patients with squamous cell abnormalities found in cervical 
      cytologic screening. MATERIALS AND METHODS: Thirty-four (0.3%) of 1,100 patients 
      who came for their routine cervical cytologic screening and diagnosed as having 
      squamous cell abnormalities were enrolled in the study. Colposcopy-directed 
      biopsy was obtained from all study patients. HPV DNA was sought in cervical swab 
      specimens placed in Digene transport medium by the use of the Digene Hybrid 
      Capture assay. The findings of cervical cytology, colposcopy-directed biopsy and 
      HPV screening were compared. RESULTS: In a total of 34 women who were diagnosed 
      as having squamous cell abnormalities in their routine cervical cytologic 
      screening, 15 women had atypical squamous cell lesions of undetermined 
      significancy (ASCUS), 16 women had low-grade cervical intraepithelial lesions 
      (LGSIL), and three women had high-grade cervical intraepithelial lesions (HGSIL). 
      Five (15%) of these women tested positive for HPV screening in cervical swabs 
      where four women had infection with high-risk and one woman had infection with 
      low-risk subtypes. None of the patients with koilocytotic changes of the squamous 
      cells in the class of LGSIL histopathologically tested positive for HPV 
      screening. In addition, one patient diagnosed as having invasive cervical 
      carcinoma histopathologically tested negative for HPV screening. Atypical 
      vascularization was seen colposcopically in this 37-year-old woman who had ASCUS 
      cytologically. CONCLUSION: HPV screening seems to have value in the triage of 
      patients with ASCUS with no clear advantage to colposcopy-directed biopsy. The 
      routine performance of HPV screening for the triage of patients with squamous 
      cell abnormalities has no advantage over colposcopy-directed biopsy.
FAU - Ozsaran, A A
AU  - Ozsaran AA
AD  - Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, 
      Izmir, Turkey.
FAU - Dikmen, Y
AU  - Dikmen Y
FAU - Akercan, F
AU  - Akercan F
FAU - Zekioglu, O
AU  - Zekioglu O
FAU - Terek, M C
AU  - Terek MC
FAU - Mgoyi, L
AU  - Mgoyi L
FAU - Altuglu, I
AU  - Altuglu I
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - Singapore
TA  - Eur J Gynaecol Oncol
JT  - European journal of gynaecological oncology
JID - 8100357
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Cohort Studies
MH  - Colposcopy
MH  - DNA, Viral/analysis
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Papillomaviridae/genetics/*isolation & purification
MH  - Predictive Value of Tests
MH  - Uterine Cervical Neoplasms/*diagnosis/pathology/virology
MH  - Vaginal Smears
MH  - Uterine Cervical Dysplasia/*diagnosis/pathology/virology
EDAT- 2003/12/09 05:00
MHDA- 2004/03/18 05:00
CRDT- 2003/12/09 05:00
PHST- 2003/12/09 05:00 [pubmed]
PHST- 2004/03/18 05:00 [medline]
PHST- 2003/12/09 05:00 [entrez]
PST - ppublish
SO  - Eur J Gynaecol Oncol. 2003;24(6):535-8.