PMID- 14659938
OWN - NLM
STAT- MEDLINE
DCOM- 20040311
LR  - 20171116
IS  - 0045-6535 (Print)
IS  - 0045-6535 (Linking)
VI  - 54
IP  - 10
DP  - 2004 Mar
TI  - Metabolism, tissue disposition, and excretion of 
      1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) in male Sprague-Dawley rats.
PG  - 1367-74
AB  - A single oral dose of [14C] 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) was 
      administered to conventional and bile-duct cannulated male Sprague-Dawley rats. 
      Tissue disposition, excretion and metabolism was determined. BTBPE is a 
      low-volume brominated flame retardant used in resins or plastics, and toxicity 
      data in peer-reviewed journals is extremely limited. BTBPE was fairly insoluble 
      in lipophilic solutions, which made dose preparation difficult. The great 
      majority of 14C (>94%) was excreted in the feces of both groups of rats at 72 h, 
      and tissue retention was minimal. Lipophilic tissues contained the highest 
      concentrations of BTBPE, e.g. thymus, adipose tissue, adrenals, lung, and skin. 
      Metabolites were excreted in the urine, bile and feces, but at a very low level. 
      Fecal metabolites were characterized as monohydroxylated, monohydroxylated with 
      debromination, dihydroxylated/debrominated on a single aromatic ring, 
      monohydroxylated on each aromatic ring with accompanying debromination, and 
      cleavage on either side of the ether linkage to yield tribromophenol and 
      tribromophenoxyethanol. Despite a limited quantity of stable metabolites 
      extractable in the feces, non-extractable 14C levels were relatively high (39% of 
      the 0-24 h fecal 14C), which suggested that BTBPE could be metabolically 
      activated in the rat and covalently bound to fecal proteins and/or lipids. It was 
      concluded that limited absorption and metabolism of BTBPE would occur by 
      ingestion in mammals.
FAU - Hakk, Heldur
AU  - Hakk H
AD  - USDA, ARS, Biosciences Research Laboratory, 1605 Albrecht Blvd, PO Box 5674, 
      University Station, Fargo, ND 58105-5647, USA. hakkh@fargo.ars.usda.gov
FAU - Larsen, Gerald
AU  - Larsen G
FAU - Bowers, Joseph
AU  - Bowers J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Bromobenzenes)
RN  - 0 (Carbon Radioisotopes)
RN  - 0 (Flame Retardants)
RN  - 34I00D6RNM (1,2-bis(2,4,6-tribromophenoxy)ethane)
SB  - IM
MH  - Animals
MH  - Bile/metabolism
MH  - Bromobenzenes/*pharmacokinetics
MH  - Carbon Radioisotopes/blood/*metabolism/urine
MH  - Chromatography
MH  - Feces/chemistry
MH  - Flame Retardants/*pharmacokinetics
MH  - Lipid Metabolism
MH  - Male
MH  - Mass Spectrometry
MH  - Rats/*metabolism
MH  - Rats, Sprague-Dawley
EDAT- 2003/12/09 05:00
MHDA- 2004/03/12 05:00
CRDT- 2003/12/09 05:00
PHST- 2003/12/09 05:00 [pubmed]
PHST- 2004/03/12 05:00 [medline]
PHST- 2003/12/09 05:00 [entrez]
AID - S0045-6535(03)01046-4 [pii]
AID - 10.1016/j.chemosphere.2003.10.032 [doi]
PST - ppublish
SO  - Chemosphere. 2004 Mar;54(10):1367-74. doi: 10.1016/j.chemosphere.2003.10.032.