PMID- 14660058
OWN - NLM
STAT- MEDLINE
DCOM- 20040428
LR  - 20171116
IS  - 1025-3890 (Print)
IS  - 1025-3890 (Linking)
VI  - 6
IP  - 4
DP  - 2003 Dec
TI  - Stressor exposure produces long-term reductions in antigen-specific T and B cell 
      responses.
PG  - 259-67
AB  - Exposure to an acute laboratory stressor at the time of keyhole limpet hemocyanin 
      (KLH) immunization results in a long-term suppression in circulating anti-KLH 
      antibody. The mechanism for the stress-induced reduction in anti-KLH 
      immunoglobulin (Ig) remains unknown. Given that the generation of anti-KLH 
      antibody requires T cell help, we hypothesize that stress reduces the 
      proliferation of anti-KLH T cells, thus leading to a reduction in anti-KLH 
      antibody. The present studies examined the effect of tail shock stress (100, 1.6 
      mA, 5-s, 60 s ITI) on the KLH specific T cell response. Fischer F344 rats were 
      immunized either intraperitoneally (i.p.) or subcutaneously (s.c.) at the base of 
      the tail with 200 microg KLH, and exposed to inescapable tail shock (IS) or 
      remained in their home cages (HCC). T cell proliferation after KLH restimulation, 
      but not ConA, was markedly suppressed in IS animals in both the spleen after i.p. 
      immunization and the draining lymph nodes after s.c. immunization. Other 
      secondary lymphoid cells did not differ in their proliferative capacity. Anti-KLH 
      IgG, IgG1 and IgG2a, but not anti-KLH IgM serum levels were significantly 
      suppressed. These data support the conclusion that stress suppresses the 
      generation of antigen specific T cells. In addition, the methods employed in the 
      current study allow the isolation of the site of the acquired T cell immune 
      response, making it possible to further elucidate the cellular mechanisms that 
      contribute to stress-induced modulation of the antigen-specific acquired immune 
      response.
FAU - Gazda, Lawrence S
AU  - Gazda LS
AD  - Department of Psychology, University of Colorado at Boulder, CO 80309-0354, USA.
FAU - Smith, Taro
AU  - Smith T
FAU - Watkins, Linda R
AU  - Watkins LR
FAU - Maier, Steven F
AU  - Maier SF
FAU - Fleshner, Monika
AU  - Fleshner M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Stress
JT  - Stress (Amsterdam, Netherlands)
JID - 9617529
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Antigens)
RN  - 0 (Epitopes)
RN  - 11028-71-0 (Concanavalin A)
RN  - 9013-72-3 (Hemocyanins)
RN  - FV4Y0JO2CX (keyhole-limpet hemocyanin)
SB  - IM
MH  - Adjuvants, Immunologic/pharmacology
MH  - Animals
MH  - Antigens/*immunology
MH  - B-Lymphocytes/drug effects/*immunology
MH  - Cell Division/drug effects
MH  - Concanavalin A/administration & dosage
MH  - Electroshock
MH  - Epitopes
MH  - Hemocyanins/immunology/pharmacology
MH  - Immunization
MH  - Injections, Intraperitoneal
MH  - Injections, Subcutaneous
MH  - Male
MH  - Rats
MH  - Rats, Inbred F344
MH  - Spleen/cytology
MH  - Stress, Physiological/etiology/*immunology
MH  - T-Lymphocytes/cytology/drug effects/*immunology
EDAT- 2003/12/09 05:00
MHDA- 2004/04/29 05:00
CRDT- 2003/12/09 05:00
PHST- 2003/12/09 05:00 [pubmed]
PHST- 2004/04/29 05:00 [medline]
PHST- 2003/12/09 05:00 [entrez]
AID - GV1FT7Q51UPX6MMA [pii]
AID - 10.1080/10253890310001594441 [doi]
PST - ppublish
SO  - Stress. 2003 Dec;6(4):259-67. doi: 10.1080/10253890310001594441.