PMID- 14667476
OWN - NLM
STAT- MEDLINE
DCOM- 20040220
LR  - 20240109
IS  - 0278-6915 (Print)
IS  - 0278-6915 (Linking)
VI  - 42
IP  - 2
DP  - 2004 Feb
TI  - Toxicity of hypercaloric diet and monosodium glutamate: oxidative stress and 
      metabolic shifting in hepatic tissue.
PG  - 313-19
AB  - The present study examines the effects of a hypercaloric diet on hepatic glucose 
      metabolism of young rats, with and without monosodium glutamate (MSG) 
      administration, and the association of these treatments with evaluating markers 
      of oxidative stress. Male weaned Wistar rats (21 days old) from mothers fed with 
      a hypercaloric diet or a normal diet, were divided into four groups (n=6): 
      control (C) fed with control diet; (MSG) treated with MSG (4 mg/g) and control 
      diet; (HD) fed with hypercaloric diet and (MSG-HD) treated with MSG and HD. Rats 
      were sacrificed after the oral glucose tolerance test (OGTT), at 45 days of 
      treatments. Serum was used for insulin determination. Glycogen, hexokinase(HK), 
      glucose-6-phosphatase(G6PH), lipid hydroperoxide, superoxide dismutase(SOD) and 
      glutathione peroxidase(GSH-Px) were determined in liver. HD rats showed 
      hypoglycemia, hyperinsulinemia, and high hepatic glycogen, HK and decreased G6PH. 
      MSG and MSG-HD had hyperinsulinemia, hyperglycemia, decreased HK and increased 
      G6PH in hepatic tissue. These animals had impaired OGTT. HD, MSG and MSG-HD 
      groups had increased lipid hydroperoxide and decreased SOD in hepatic tissue. 
      Hypercaloric diet and monosodium glutamate administration induced alterations in 
      metabolic rate of glucose utilization and decreased antioxidant defenses. 
      Therefore, the hepatic glucose metabolic shifting induced by HD intake and MSG 
      administration were associated with oxidative stress in hepatic tissue.
FAU - Diniz, Yeda S
AU  - Diniz YS
AD  - Post Graduation Course Department of Clinical and Cardiology, Faculty of 
      Medicine, UNESP, Botucatu, Sao Paulo, Brazil.
FAU - Fernandes, Ana A H
AU  - Fernandes AA
FAU - Campos, Kleber E
AU  - Campos KE
FAU - Mani, Fernanda
AU  - Mani F
FAU - Ribas, Bartolome O
AU  - Ribas BO
FAU - Novelli, Ethel L B
AU  - Novelli EL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Flavoring Agents)
RN  - 0 (Insulin)
RN  - IY9XDZ35W2 (Glucose)
RN  - W81N5U6R6U (Sodium Glutamate)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - *Diet
MH  - Female
MH  - Flavoring Agents/administration & dosage/*pharmacology
MH  - Glucose/*metabolism
MH  - Insulin/blood
MH  - Liver/*metabolism
MH  - Male
MH  - Oxidative Stress/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Sodium Glutamate/administration & dosage/*pharmacology
EDAT- 2003/12/12 05:00
MHDA- 2004/02/21 05:00
CRDT- 2003/12/12 05:00
PHST- 2003/12/12 05:00 [pubmed]
PHST- 2004/02/21 05:00 [medline]
PHST- 2003/12/12 05:00 [entrez]
AID - S0278691503002795 [pii]
AID - 10.1016/j.fct.2003.09.006 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2004 Feb;42(2):313-19. doi: 10.1016/j.fct.2003.09.006.