PMID- 14668182
OWN - NLM
STAT- MEDLINE
DCOM- 20040601
LR  - 20061115
IS  - 1401-7431 (Print)
IS  - 1401-7431 (Linking)
VI  - 37
IP  - 6
DP  - 2003 Dec
TI  - Global dispersion of right atrial repolarization in healthy pigs and patients.
PG  - 329-33
AB  - OBJECTIVE: To investigate the feasibility of monophasic action potential (MAP) 
      mapping using an electroanatomical mapping system (CARTO) in obtaining 
      information on global dispersion of atrial repolarization and to evaluate the 
      role of dispersion of repolarization in the genesis of paroxysmal atrial 
      fibrillation (PAF). METHODS AND RESULTS: Right atrial MAPs were recorded from 53 
      +/- 18 sites in 10 healthy pigs and 33 +/- 21 sites in 6 patients with and 4 
      patients without history of PAF. In pigs, the global dispersions of activation 
      time (AT), MAP duration and end of repolarization time (EOR), 70 +/- 8, 95 +/- 18 
      and 121 +/- 28 ms, respectively, were significantly greater than those among 10, 
      20 and 30 sites. In patients with PAF, the global dispersions of MAP duration and 
      EOR (128 +/- 10 and 149 +/- 31 ms) were significantly greater than those in 
      patients without PAF (84 +/- 10 and 91 +/- 17 ms). CONCLUSION: MAP mapping using 
      the CARTO system was feasible in experimental and clinical settings in obtaining 
      information on global dispersion of atrial repolarization. The number of 
      recording sites could significantly affect repolarization parameters. The 
      dispersions of atrial repolarization were significantly greater in patients with 
      PAF than those without, suggesting the involvement of an increased dispersion of 
      repolarization in the genesis of PAF.
FAU - Hertervig, Eva
AU  - Hertervig E
AD  - Department of Cardiology, University Hospital, Lund, Sweden.
FAU - Li, Zhen
AU  - Li Z
FAU - Kongstad, Ole
AU  - Kongstad O
FAU - Holm, Magnus
AU  - Holm M
FAU - Olsson, S Bertil
AU  - Olsson SB
FAU - Yuan, Shiwen
AU  - Yuan S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Scand Cardiovasc J
JT  - Scandinavian cardiovascular journal : SCJ
JID - 9708377
SB  - IM
MH  - Action Potentials/physiology
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Animals
MH  - Atrial Function, Right/*physiology
MH  - Body Surface Potential Mapping/*methods
MH  - Electrophysiologic Techniques, Cardiac
MH  - Female
MH  - Heart Atria/anatomy & histology/*physiopathology
MH  - Heart Conduction System/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Models, Animal
MH  - Models, Cardiovascular
MH  - Swine
EDAT- 2003/12/12 05:00
MHDA- 2004/06/02 05:00
CRDT- 2003/12/12 05:00
PHST- 2003/12/12 05:00 [pubmed]
PHST- 2004/06/02 05:00 [medline]
PHST- 2003/12/12 05:00 [entrez]
AID - 8666PCHTAQ3EM8PC [pii]
AID - 10.1080/14017430310016207 [doi]
PST - ppublish
SO  - Scand Cardiovasc J. 2003 Dec;37(6):329-33. doi: 10.1080/14017430310016207.