PMID- 14668772
OWN - NLM
STAT- MEDLINE
DCOM- 20040504
LR  - 20230317
IS  - 1071-3581 (Print)
IS  - 1071-3581 (Linking)
VI  - 10
IP  - 6
DP  - 2003 Nov-Dec
TI  - Myocardial contractile reserve determined by dobutamine stress Tc-99m tetrofosmin 
      quantitative gated SPECT predicts late spontaneous improvement in cardiac 
      function in patients with recent-onset dilated cardiomyopathy.
PG  - 607-14
AB  - BACKGROUND: We evaluated whether dobutamine stress technetium 99m tetrofosmin 
      (DSTF) quantitative gated single photon emission computed tomography (QGS) could 
      predict late spontaneous improvement of cardiac function in patients with 
      idiopathic dilated cardiomyopathy (DCM). METHODS AND RESULTS: The study included 
      26 patients with recently diagnosed (<2 months) idiopathic DCM and a left 
      ventricular ejection fraction (LVEF) lower than 45%. DSTF-QGS was performed in 
      all patients to measure LVEF at rest and during dobutamine infusion (10 microg. 
      kg(-1). min(-1)). LVEF and left ventricular end-diastolic volume (LVEDV) were 
      determined by echocardiography, and New York Heart Association (NYHA) functional 
      class was estimated at baseline and after 1 year. After 1 year of treatment, the 
      echocardiographic LVEF improved by greater than 5% in 13 patients (group A) but 
      did not improve in the remaining 13 patients (group B). At baseline, the 
      echocardiographic LVEF, LVEDV, and NYHA functional class were similar in both 
      groups. However, there was a greater increase in the LVEF during the dobutamine 
      infusion portion of the DSTF-QGS (DeltaLVEF) in group A than in group B (13.1% 
      +/- 5.9% vs 2.6% +/- 4.1%, P <.0001). If a critical value for the DeltaLVEF of 
      7.0% was used to predict improvement in LVEF after treatment, the sensitivity was 
      84.7% and the specificity was 84.7%. LVEDV and NYHA functional class improved to 
      a greater extent in group A than in group B. CONCLUSIONS: DSTF-QGS can be used to 
      predict late spontaneous improvement in cardiac function and symptoms after 
      treatment in patients with idiopathic DCM.
FAU - Kasama, Shu
AU  - Kasama S
AD  - Second Department of Internal Medicine, Gunma University School of Medicine, 
      Maebashi, Japan. s-kasama@bay.wind.ne.jp
FAU - Toyama, Takuji
AU  - Toyama T
FAU - Kumakura, Hisao
AU  - Kumakura H
FAU - Takayama, Yoshiaki
AU  - Takayama Y
FAU - Ichikawa, Shuichi
AU  - Ichikawa S
FAU - Suzuki, Tadashi
AU  - Suzuki T
FAU - Kurabayashi, Masahiko
AU  - Kurabayashi M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Validation Study
PL  - United States
TA  - J Nucl Cardiol
JT  - Journal of nuclear cardiology : official publication of the American Society of 
      Nuclear Cardiology
JID - 9423534
RN  - 0 (Anti-Arrhythmia Agents)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Organotechnetium Compounds)
RN  - 0 (Radiopharmaceuticals)
RN  - 3S12J47372 (Dobutamine)
RN  - 42FOP1YX93 (technetium tc-99m tetrofosmin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-Arrhythmia Agents/therapeutic use
MH  - Antihypertensive Agents/therapeutic use
MH  - Cardiomyopathy, Dilated/complications/diagnosis/*diagnostic imaging/drug therapy
MH  - *Dobutamine
MH  - *Exercise Test
MH  - Female
MH  - Gated Blood-Pool Imaging/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Contraction
MH  - *Organophosphorus Compounds
MH  - *Organotechnetium Compounds
MH  - Radiopharmaceuticals
MH  - *Recovery of Function
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Statistics as Topic
MH  - Stroke Volume
MH  - Tomography, Emission-Computed, Single-Photon/methods
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/diagnosis/*diagnostic imaging/drug therapy/etiology
EDAT- 2003/12/12 05:00
MHDA- 2004/05/05 05:00
CRDT- 2003/12/12 05:00
PHST- 2003/12/12 05:00 [pubmed]
PHST- 2004/05/05 05:00 [medline]
PHST- 2003/12/12 05:00 [entrez]
AID - S1071358103006500 [pii]
AID - 10.1016/s1071-3581(03)00650-0 [doi]
PST - ppublish
SO  - J Nucl Cardiol. 2003 Nov-Dec;10(6):607-14. doi: 10.1016/s1071-3581(03)00650-0.