PMID- 14670119
OWN - NLM
STAT- MEDLINE
DCOM- 20040714
LR  - 20191210
IS  - 1076-3279 (Print)
IS  - 1076-3279 (Linking)
VI  - 9
IP  - 6
DP  - 2003 Dec
TI  - Technique paper for wet-spinning poly(L-lactic acid) and 
      poly(DL-lactide-co-glycolide) monofilament fibers.
PG  - 1323-30
AB  - A simple and repeatable method is described for wet-spinning poly(L-lactic acid) 
      (PLLA) and poly(DL-lactic-co-glycolic acid) (PLGA) monofilament fibers. These 
      fibers are strong, elastic, and suitable for many applications, including use as 
      tissue-engineering scaffolds. The PLLA wet-extruded fibers do not show additional 
      strain-induced crystallization as a result of drawing the fibers during 
      fabrication; however, there is an apparent increase in crystallinity late in the 
      degradation process in saline at 37 degrees C. We have measured the molecular 
      weight degradation in saline at 37 degrees C for fibers of both PLLA and PLGA. 
      Changing solvent systems, polymer blends, and winding rates alters mechanical and 
      morphological properties of these fibers for specific applications. The authors 
      discuss a possible theoretical explanation for these observed changes due to 
      changes in polymer concentration, solvent system, and coagulation bath 
      properties. This wet-extrusion process is simple and inexpensive enough to be 
      carried out in almost any laboratory interested in tissue engineering.
FAU - Nelson, Kevin D
AU  - Nelson KD
AD  - Joint Program in Biomedical Engineering, University of Texas Southwestern Medical 
      Center at Dallas, Dallas, Texas 76019-0138, USA. knelson@uta.edu
FAU - Romero, Andres
AU  - Romero A
FAU - Waggoner, Paula
AU  - Waggoner P
FAU - Crow, Brent
AU  - Crow B
FAU - Borneman, Angela
AU  - Borneman A
FAU - Smith, George M
AU  - Smith GM
LA  - eng
GR  - R01 NS 40592-01/NS/NINDS NIH HHS/United States
PT  - Evaluation Study
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Technical Report
PL  - United States
TA  - Tissue Eng
JT  - Tissue engineering
JID - 9505538
RN  - 0 (Biocompatible Materials)
RN  - 0 (Membranes, Artificial)
RN  - 0 (Polyesters)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 459TN2L5F5 (poly(lactide))
SB  - IM
MH  - Absorbable Implants
MH  - Biocompatible Materials/chemical synthesis/*chemistry
MH  - Biomimetic Materials/chemical synthesis/*chemistry
MH  - Elasticity
MH  - Extracellular Matrix/*chemistry
MH  - Hot Temperature
MH  - Lactic Acid/*chemistry
MH  - Materials Testing
MH  - Membranes, Artificial
MH  - Molecular Conformation
MH  - Molecular Weight
MH  - Polyesters
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*chemistry
MH  - Rotation
MH  - Surface Properties
MH  - Tensile Strength
MH  - Textiles
MH  - Tissue Engineering/*methods
MH  - Wettability
EDAT- 2003/12/13 05:00
MHDA- 2004/07/15 05:00
CRDT- 2003/12/13 05:00
PHST- 2003/12/13 05:00 [pubmed]
PHST- 2004/07/15 05:00 [medline]
PHST- 2003/12/13 05:00 [entrez]
AID - 10.1089/10763270360728233 [doi]
PST - ppublish
SO  - Tissue Eng. 2003 Dec;9(6):1323-30. doi: 10.1089/10763270360728233.